Concepedia

Small-molecule Complement Inhibitors

Small-Molecule Complement Inhibitor is a pharmacological agent that belongs to the class of complement-targeted therapies and is distinguished by its low molecular weight, enabling oral bioavailability and specific modulation of complement system proteins to inhibit pathological immune activation.

92

Publications

5.3K

Citations

743

Authors

255

Institutions

Publications per year

2017–2026

27

Parents

Publications

92

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

Marceline Côté, John Misasi, Tao Ren et al. · Nature · 2011 · 694 citations · Full text

, , +14

Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

Richard J. Kelly, Britta Höchsmann, Jeff Szer et al. · New England Journal of Medicine · 2015 · 275 citations · Full text

, , +17

Low-Molecular-Weight Peptidic and Cyclic Antagonists of the Receptor for the Complement Factor C5a

Angela M. Finch, A. K. Wong, Natalii J. Paczkowski et al. · Journal of Medicinal Chemistry · 1999 · 244 citations · Full text

, , +15

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Anna Schubart, Karen Anderson, Nello Mainolfi et al. · Proceedings of the National Academy of Sciences · 2019 · 216 citations · Full text

, , +17

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang et al. · Blood · 2014 · 195 citations · Full text

, , +11

1–5 of 92

Authors

743

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    8 publications · 531 citations

    8

    h-index

  2. DR
    Daniel Ricklin

    University of Pennsylvania, United States

    7 publications · 506 citations

    7

    h-index

  3. AM
    Antonio M. Risitano

    University of Naples Federico II, Italy

    6 publications · 901 citations

    6

    h-index

  4. KA
    Karen Anderson

    University of California San Diego, United States

    6 publications · 425 citations

    6

    h-index

  5. FC
    Frédéric Cumin

    Novartis (Switzerland), Switzerland

    5 publications · 404 citations

    5

    h-index

1–5 of 743

Institutions

255

  1. Novartis (Switzerland)

    Basel, Switzerland

    10 h-index

    102 publications

    8.9K citations

  2. University of Pennsylvania

    Philadelphia, United States

    8 h-index

    26 publications

    2.3K citations

  3. University of Mississippi

    Oxford, United States

    6 h-index

    17 publications

    433 citations

  4. Novartis (United States)

    New York, United States

    6 h-index

    84 publications

    3.3K citations

  5. Cardiff University

    Cardiff, United Kingdom

    5 h-index

    11 publications

    837 citations

  6. Washington University in St. Louis

    St Louis, United States

    5 h-index

    14 publications

    962 citations

  7. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    5 h-index

    31 publications

    1.2K citations

  8. University of Naples Federico II

    Naples, Italy

    4 h-index

    9 publications

    1.5K citations

1–8 of 255

Venues

  1. Blood

    10 publications · 570 citations

    10

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    9 publications · 183 citations

    9

    h-index

  3. Journal of Medicinal Chemistry

    7 publications · 558 citations

    7

    h-index

  4. Molecular Immunology

    6 publications · 139 citations

    6

    h-index

  5. The Journal of Immunology

    JI · 5 publications · 153 citations

    5

    h-index

1–5