Concepedia

Complement System Pharmacology

Complement System Pharmacology is a specialized branch of immunopharmacology that focuses on the modulation of the complement system's biochemical cascade for therapeutic intervention in immune-mediated diseases.

283

Publications

16.7K

Citations

2.4K

Authors

686

Institutions

Publications per year

2017–2026

101

Parents

Children

Publications

283

The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, Neal S. Young, Jörg Schubert et al. · New England Journal of Medicine · 2006 · 1.3K citations · Full text

, , +17

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

Russell P. Rother, Scott A. Rollins, Christopher F. Mojcik et al. · Nature Biotechnology · 2007 · 764 citations

, , +13

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Takashi Kishimoto, Karthik Viswanathan, Tanmoy Ganguly et al. · New England Journal of Medicine · 2008 · 616 citations · Full text

, , +12

Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases

Suzan H. M. Rooijakkers, Maartje Ruyken, Anja Roos et al. · Nature Immunology · 2005 · 445 citations

, , +16

Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies

Christoph Licht, Larry A. Greenbaum, Petra Muus et al. · Kidney International · 2015 · 415 citations · Full text

, , +17

1–5 of 283

Authors

2.4K

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    13 publications · 635 citations

    13

    h-index

  2. AR
    Alexander Röth

    University of Duisburg-Essen, Germany

    10 publications · 1.7K citations

    10

    h-index

  3. SO
    Stephan Ortiz

    Alexion Pharmaceuticals (United States), United States

    7 publications · 545 citations

    7

    h-index

  4. TM
    Trent M. Woodruff

    The University of Queensland, Australia

    7 publications · 264 citations

    7

    h-index

  5. WB
    Wilma Barcellini

    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy

    7 publications · 257 citations

    7

    h-index

1–5 of 2.4K

Institutions

686

  1. Alexion Pharmaceuticals (United States)

    Boston, United States

    24 h-index

    98 publications

    19K citations

  2. University of Pennsylvania

    Philadelphia, United States

    13 h-index

    43 publications

    3K citations

  3. The University of Queensland

    Brisbane, Australia

    12 h-index

    81 publications

    4.4K citations

  4. University of Duisburg-Essen

    Essen, Germany

    11 h-index

    17 publications

    597 citations

  5. Harvard University

    Cambridge, United States

    11 h-index

    15 publications

    1.4K citations

  6. The University of Osaka

    Osaka, Japan

    11 h-index

    28 publications

    3K citations

  7. University College London

    London, United Kingdom

    10 h-index

    19 publications

    1.2K citations

  8. Assistance Publique – Hôpitaux de Paris

    Paris, France

    9 h-index

    31 publications

    3.5K citations

1–8 of 686

Venues

  1. PubMed

    Repository · 21 publications · 759 citations

    15

    h-index

  2. Journal of Medicinal Chemistry

    14 publications · 606 citations

    13

    h-index

  3. The Journal of Immunology

    JI · 12 publications · 491 citations

    12

    h-index

  4. Blood Advances

    8 publications · 430 citations

    8

    h-index

  5. Blood

    8 publications · 242 citations

    7

    h-index

1–5