Concepedia

Site-selective Covalent Binding

Site-Selective Covalent Binding is a covalent modification strategy in which a chemical agent forms a stable bond with a specific nucleophilic residue within a biomacromolecule, distinguished by its precise spatial and chemoselective targeting enabled by molecular recognition and reactivity tuning.

57

Publications

3.3K

Citations

334

Authors

118

Institutions

Publications per year

2017–2026

19

Parents

Publications

57

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

John K. Eaton, Laura Furst, Richard A. Ruberto et al. · Nature Chemical Biology · 2020 · 472 citations · Full text

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A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue

Olle Larm, Rolf Larsson, Per Olsson · Biomaterials Medical Devices and Artificial Organs · 1983 · 439 citations

, , +15

Solvent-Sensitive Dyes to Report Protein Conformational Changes in Living Cells

Alexei Toutchkine, Vadim S. Kraynov, Klaus M. Hahn · Journal of the American Chemical Society · 2003 · 162 citations

, , +17

Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.

John A. Katzenellenbogen, Kathryn E. Carlson, Daniel F. Heiman et al. · Journal of Biological Chemistry · 1983 · 152 citations · Full text

, , +14

Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy

Li‐Xi Liao, Xiaomin Song, Lichao Wang et al. · Proceedings of the National Academy of Sciences · 2017 · 150 citations · Full text

, , +17

1–5 of 57

Authors

334

  1. AO
    Akio Ojida

    Kyushu University, Japan

    2 publications · 115 citations

    2

    h-index

  2. IH
    Itaru Hamachi

    Kyoto University, Japan

    2 publications · 98 citations

    2

    h-index

  3. RW
    Rui Wang

    Peking University, China

    2 publications · 39 citations

    2

    h-index

  4. JX
    Jiang Xia

    Chinese University of Hong Kong, Hong Kong SAR China

    2 publications · 39 citations

    2

    h-index

  5. LL
    Linting Li

    Chinese University of Hong Kong, Hong Kong SAR China

    2 publications · 39 citations

    2

    h-index

1–5 of 334

Institutions

118

  1. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    3 h-index

    12 publications

    418 citations

  2. Harvard University

    Cambridge, United States

    3 h-index

    9 publications

    708 citations

  3. Kyushu University

    Fukuoka, Japan

    2 h-index

    14 publications

    466 citations

  4. City University of Hong Kong

    Hong Kong, Hong Kong

    2 h-index

    4 publications

    78 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    9 publications

    399 citations

  6. China Pharmaceutical University

    Nanjing, China

    2 h-index

    11 publications

    710 citations

  7. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    2 publications

    98 citations

  8. Kyoto University

    Kyoto, Japan

    2 h-index

    9 publications

    516 citations

1–8 of 118

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 267 citations

    5

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 280 citations

    4

    h-index

  3. Chemical Communications

    ChemComm · 3 publications · 158 citations

    3

    h-index

  4. Biochemistry

    3 publications · 66 citations

    3

    h-index

  5. Bioorganic & Medicinal Chemistry

    2 publications · 54 citations

    2

    h-index

1–5