Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Lichao Wang, Binsheng Wang, Nathan Gasek, +23

Cell Metabolism

ObesityMetabolic SyndromeInsulin ResistanceInsulin SignalingSignal Transduction +11

Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy

Li‐Xi Liao, Xiaomin Song, Lichao Wang, +8

Proceedings of the National Academy of Sciences

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

Justin Guinney, Tao Wang, Teemu D. Laajala, +192

The Lancet Oncology

Prognostic BiomarkersUrologyMedicinePredictive AnalyticsPrognosis +8

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Binsheng Wang, Lichao Wang, Nathan Gasek, +10

Nature Aging

Knockout MouseSignal TransductionCell RegulationNatural SciencesCell Interaction +7

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Yueying Zhou, Xiaonan Xin, Lichao Wang, +5

npj Regenerative Medicine

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Binsheng Wang, Zukai Liu, Vicky P. Chen, +10

Aging Cell

An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid

Lichao Wang, Wen-Hui Wei, Xiaowen Zhang, +3

Frontiers in Pharmacology

Integration of Metabolomics With Pharmacodynamics to Elucidate the Anti-myocardial Ischemia Effects of Combination of Notoginseng Total Saponins and Safflower Total Flavonoids

Yuqing Meng, Zhiyong Du, Yan Li, +8

Frontiers in Pharmacology

The Ethanolic Extract of Caesalpinia sappan Heartwood Inhibits Cerebral Ischemia/Reperfusion Injury in a Rat Model Through a Multi-Targeted Pharmacological Mechanism

Yanjun Wan, Li Xu, Wenting Song, +7

Frontiers in Pharmacology

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Binsheng Wang, Lichao Wang, Nathan Gasek, +23

Cell Metabolism

Lifespan ExtensionAgingAnti-agingCell RegulationLongevity +11