Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy

Li‐Xi Liao, Xiaomin Song, Lichao Wang, +8

Proceedings of the National Academy of Sciences

Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways

Fangjiao Song, Ke‐Wu Zeng, Li‐Xi Liao, +3

PLoS ONE

Nitric OxideImmunologyImmune RegulationCell DeathInhibiting Traf6-nf-κb +21

Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Ke‐Wu Zeng, Jingkang Wang, Lichao Wang, +10

Signal Transduction and Targeted Therapy

Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition

Li‐Xi Liao, Hai‐Ning Lv, Dan Liu, +9

EBioMedicine

TDB protects vascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced injury by targeting miR-34a to increase Bcl-2 expression

Li‐Xi Liao, Mingbo Zhao, Xin Dong, +3

Scientific Reports

Mitochondrial DysfunctionImmunologyCell DeathAbstract Prolonged IschemiaVascular Endothelial Cells +17

Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways

Ke‐Wu Zeng, Qian Yu, Fangjiao Song, +5

European Journal of Pharmacology

ImmunologyP38/erk Mapk PathwaysSocial SciencesOxidative StressNeuroinflammation +14

Anti‐Neuroinflammatory Effect of MC13, a Novel Coumarin Compound From Condiment Murraya, Through Inhibiting Lipopolysaccharide‐Induced TRAF6‐TAK1‐NF‐κB, P38/ERK MAPKS and Jak2‐Stat1/Stat3 Pathways

Ke‐Wu Zeng, Qian Yu, Li‐Xi Liao, +4

Journal of Cellular Biochemistry

Inhibiting Lipopolysaccharide‐induced Traf6‐tak1‐nf‐κbImmunotoxicologyJak2‐stat1/stat3 PathwaysImmunologyImmune Regulation +20

Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax

Shaoyang Zhao, Li‐Xi Liao, Pengfei Tu, +2

Oxidative Medicine and Cellular Longevity

Protosappanin B protects PC12 cells against oxygen–glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation

Ke‐Wu Zeng, Li‐Xi Liao, Mingbo Zhao, +4

European Journal of Pharmacology

Pc12 CellsProtosappanin BMedicineMitochondrial HomeostasisApoptosis +9

Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia

Lichao Wang, Li‐Xi Liao, Mingbo Zhao, +3

Chinese Journal of Natural Medicines

InflammationAnti-inflammatoryMedicineExerts Anti-neuroinflammatory EffectAutophagy +10