Concepedia

Single-chain Variable Fragments

Single-Chain Variable Fragment is a recombinant antibody fragment comprising the variable regions of the heavy and light chains of an immunoglobulin, connected by a short, flexible peptide linker, enabling antigen binding with a minimized, monovalent structure.

763

Publications

32.1K

Citations

5.1K

Authors

1.3K

Institutions

Publications per year

2017–2026

272

Variants

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Parents

Publications

763

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

Carmine Carpenito, Michael C. Milone, Raffit Hassan et al. · Proceedings of the National Academy of Sciences · 2009 · 889 citations · Full text

, , +17

Antibody fragments

Aaron Nelson · mAbs · 2010 · 444 citations · Full text

, , +17

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Eric L. Smith, Kim Harrington, Reed Masakayan et al. · Science Translational Medicine · 2019 · 385 citations · Full text

, , +17

Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains

Leah Alabanza, Melissa A. Pegues, Claudia Geldres et al. · Molecular Therapy · 2017 · 349 citations · Full text

, , +17

Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor

Scott Wilkie, Gianfranco Picco, Julie Foster et al. · The Journal of Immunology · 2008 · 346 citations · Full text

, , +17

1–5 of 763

Authors

5.1K

  1. XL
    Xianjin Liu

    Jiangsu Academy of Agricultural Sciences, China

    9 publications · 217 citations

    8

    h-index

  2. SD
    Stefan Dübel

    Technische Universität Braunschweig, Germany

    8 publications · 382 citations

    8

    h-index

  3. RE
    Roland E. Kontermann

    University of Stuttgart, Germany

    8 publications · 277 citations

    8

    h-index

  4. CZ
    Cunzheng Zhang

    Jiangsu Academy of Agricultural Sciences, China

    7 publications · 166 citations

    7

    h-index

  5. HT
    Hiroyuki Tanaka

    Kyushu University, Japan

    7 publications · 161 citations

    7

    h-index

1–5 of 5.1K

Institutions

1.3K

  1. University of Pennsylvania

    Philadelphia, United States

    15 h-index

    105 publications

    14.2K citations

  2. National Institutes of Health

    Bethesda, United States

    14 h-index

    51 publications

    5.3K citations

  3. National Cancer Institute

    Bethesda, United States

    14 h-index

    41 publications

    6.6K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    41 publications

    1.2K citations

  5. Harvard University

    Cambridge, United States

    11 h-index

    48 publications

    1.7K citations

  6. University of Alberta

    Edmonton, Canada

    10 h-index

    32 publications

    1.3K citations

  7. Kyushu University

    Fukuoka, Japan

    10 h-index

    41 publications

    898 citations

  8. Cornell University

    Ithaca, United States

    10 h-index

    29 publications

    1.5K citations

1–8 of 1.3K

Venues

  1. mAbs

    33 publications · 1.4K citations

    24

    h-index

  2. PubMed

    Repository · 23 publications · 1K citations

    18

    h-index

  3. The Journal of Immunology

    JI · 19 publications · 1.4K citations

    17

    h-index

  4. Scientific Reports

    24 publications · 847 citations

    17

    h-index

  5. PLoS ONE

    27 publications · 1K citations

    16

    h-index

1–5