Concepedia

Single-chain Variable Fragment Libraries

Single-Chain Variable Fragment Library is a recombinant antibody library constructed by fusing the variable heavy and light chain genes of immunoglobulins via a flexible peptide linker into a single gene sequence, enabling the display of functional antigen-binding domains on the surface of bacteriophages for high-throughput screening in phage display systems.

292

Publications

10.9K

Citations

1.9K

Authors

576

Institutions

Publications per year

2017–2026

81

Variants

Scfv Libraries

Parents

Publications

292

Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system

Anke Krebber, Susanne Bornhauser, Jörg Burmester et al. · Journal of Immunological Methods · 1997 · 490 citations

, , +17

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Eric L. Smith, Kim Harrington, Reed Masakayan et al. · Science Translational Medicine · 2019 · 385 citations · Full text

, , +17

A helper phage to improve single-chain antibody presentation in phage display

Susanne Rondot, Joachim Koch, Frank Breitling et al. · Nature Biotechnology · 2001 · 296 citations

, , +16

Generation and Application of Type-specific Anti-Heparan Sulfate Antibodies Using Phage Display Technology

Toin H. Van Kuppevelt, Michel A.B.A. Dennissen, Walther J. van Venrooij et al. · Journal of Biological Chemistry · 1998 · 263 citations · Full text

, , +17

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

Sucharitha Balu, Rajko Reljić, Melanie J. Lewis et al. · The Journal of Immunology · 2011 · 192 citations · Full text

, , +17

1–5 of 292

Authors

1.9K

  1. MH
    Michael Hust

    Technische Universität Braunschweig, Germany

    8 publications · 384 citations

    8

    h-index

  2. CZ
    Cunzheng Zhang

    Jiangsu Academy of Agricultural Sciences, China

    8 publications · 201 citations

    8

    h-index

  3. XL
    Xianjin Liu

    Jiangsu Academy of Agricultural Sciences, China

    9 publications · 228 citations

    8

    h-index

  4. CL
    Chi‐Hsin Lee

    Taipei Medical University, Taiwan

    7 publications · 148 citations

    7

    h-index

  5. SL
    Sy‐Jye Leu

    Taipei Medical University, Taiwan

    6 publications · 137 citations

    6

    h-index

1–5 of 1.9K

Institutions

576

  1. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    54 publications

    2.1K citations

  2. Technische Universität Braunschweig

    Braunschweig, Germany

    8 h-index

    31 publications

    1.7K citations

  3. Taipei Medical University

    Taipei, Taiwan

    8 h-index

    47 publications

    1K citations

  4. Jiangsu Academy of Agricultural Sciences

    Nanjing, China

    7 h-index

    48 publications

    957 citations

  5. National Institutes of Health

    Bethesda, United States

    6 h-index

    15 publications

    1.2K citations

  6. University of California, San Francisco

    San Francisco, United States

    6 h-index

    28 publications

    1.3K citations

  7. Wan Fang Hospital

    Taipei, Taiwan

    6 h-index

    6 publications

    127 citations

  8. All India Institute of Medical Sciences

    New Delhi, India

    5 h-index

    33 publications

    735 citations

1–8 of 576

Venues

  1. mAbs

    18 publications · 571 citations

    16

    h-index

  2. Journal of Biological Chemistry

    JBC · 14 publications · 801 citations

    14

    h-index

  3. PLoS ONE

    11 publications · 383 citations

    10

    h-index

  4. BMC Biotechnology

    9 publications · 406 citations

    9

    h-index

  5. Journal of Immunological Methods

    8 publications · 694 citations

    8

    h-index

1–5