Concepedia

Single-cell Genotype-phenotype Mapping

Single-Cell Genotype-Phenotype Mapping is a computational and experimental framework that resolves the relationship between individual genetic variants and their associated phenotypic outcomes at the resolution of single cells, enabling the direct linking of genotype to molecular or cellular phenotypes within heterogeneous cell populations.

29

Publications

3.9K

Citations

227

Authors

105

Institutions

Publications per year

2017–2026

22

Parents

Publications

29

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Joseph M. Replogle, Reuben A. Saunders, Angela N. Pogson et al. · Cell · 2022 · 663 citations · Full text

, , +15

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

Andrew Ransick, Nils O. Lindström, Jing Liu et al. · Developmental Cell · 2019 · 462 citations · Full text

, , +14

Automated mapping of phenotype space with single-cell data

Nikolay Samusik, Zinaida Good, Matthew H. Spitzer et al. · Nature Methods · 2016 · 461 citations

, , +16

Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Djamel Nehar-Belaid, Seunghee Hong, Radu Marcheş et al. · Nature Immunology · 2020 · 433 citations · Full text

, , +14

Mapping the Genetic Landscape of Human Cells

Max A. Horlbeck, Albert Xu, Min Wang et al. · Cell · 2018 · 347 citations · Full text

, , +14

1–5 of 29

Authors

227

  1. JS
    Jonathan S. Weissman

    Howard Hughes Medical Institute, United States

    5 publications · 1.2K citations

    5

    h-index

  2. SR
    Soumya Raychaudhuri

    Brigham and Women's Hospital, United States

    3 publications · 399 citations

    3

    h-index

  3. NY
    Nir Yosef

    University of California, Berkeley, United States

    3 publications · 74 citations

    3

    h-index

  4. MK
    Martin Kim

    University of California, Berkeley, United States

    2 publications · 46 citations

    2

    h-index

  5. JL
    José L. McFaline‐Figueroa

    University of Washington, United States

    2 publications · 46 citations

    2

    h-index

1–5 of 227

Institutions

105

  1. Harvard University

    Cambridge, United States

    8 h-index

    47 publications

    5.8K citations

  2. Broad Institute

    Cambridge, United States

    6 h-index

    45 publications

    4.4K citations

  3. University of California, San Francisco

    San Francisco, United States

    6 h-index

    33 publications

    9.6K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    20 publications

    6.7K citations

  5. Stanford University

    Stanford, United States

    5 h-index

    11 publications

    3.5K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    4 h-index

    18 publications

    6K citations

  7. Chan Zuckerberg Initiative (United States)

    Redwood City, United States

    4 h-index

    6 publications

    971 citations

  8. Whitehead Institute for Biomedical Research

    Cambridge, United States

    4 h-index

    20 publications

    6.1K citations

1–8 of 105

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 249 citations

    6

    h-index

  2. Nature Methods

    3 publications · 609 citations

    3

    h-index

  3. Cell

    2 publications · 1K citations

    2

    h-index

  4. Nature Genetics

    2 publications · 434 citations

    2

    h-index

  5. Nature Biotechnology

    2 publications · 179 citations

    2

    h-index

1–5