Concepedia

Seed Sequence Recognition

Seed Sequence Recognition is a molecular interaction mechanism in microRNA biology whereby a microRNA guides the RNA-induced silencing complex to target messenger RNAs through base-pairing complementarity centered on a conserved six- to eight-nucleotide region at the 5′ end of the microRNA, distinguishing it from other modes of post-transcriptional regulation by its specificity for this short, seed-mediated binding event.

78

Publications

8K

Citations

433

Authors

186

Institutions

Publications per year

2017–2026

32

Parents

Publications

78

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

Aimee L. Jackson, Julja Burchard, Janell M. Schelter et al. · RNA · 2006 · 962 citations · Full text

, , +17

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

Amanda Birmingham, Emily M. Anderson, Angela Reynolds et al. · Nature Methods · 2006 · 907 citations

, , +14

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

Rubén García-Martín, Guoxiao Wang, Bruna B. Brandão et al. · Nature · 2021 · 753 citations · Full text

, , +16

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

Chanseok Shin, Jin‐Wu Nam, Kyle Kai-How Farh et al. · Molecular Cell · 2010 · 619 citations · Full text

, , +13

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

Blake Wiedenheft, Esther van Duijn, Jelle B. Bultema et al. · Proceedings of the National Academy of Sciences · 2011 · 463 citations · Full text

, , +13

1–5 of 78

Authors

433

  1. ME
    Marcus E. Peter

    University of Chicago, United States

    5 publications · 109 citations

    5

    h-index

  2. AE
    Andrea E. Murmann

    Northwestern University, United States

    5 publications · 109 citations

    5

    h-index

  3. ET
    Elizabeth T. Bartom

    Northwestern University, United States

    5 publications · 109 citations

    5

    h-index

  4. MP
    Monal Patel

    Northwestern University, United States

    3 publications · 48 citations

    3

    h-index

  5. DP
    David P. Bartel

    Whitehead Institute for Biomedical Research, United States

    3 publications · 701 citations

    3

    h-index

1–5 of 433

Institutions

186

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    20 publications

    5.7K citations

  2. Northwestern University

    Evanston, United States

    6 h-index

    37 publications

    863 citations

  3. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    24 publications

    2K citations

  4. Stanford University

    Stanford, United States

    4 h-index

    9 publications

    1.4K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    17 publications

    4.1K citations

  6. Northwestern Medicine

    Chicago, United States

    3 h-index

    3 publications

    75 citations

  7. Whitehead Institute for Biomedical Research

    Cambridge, United States

    3 h-index

    17 publications

    4.1K citations

  8. University of Chicago

    Chicago, United States

    3 h-index

    4 publications

    105 citations

1–8 of 186

Venues

  1. Nucleic Acids Research

    5 publications · 375 citations

    5

    h-index

  2. PLoS ONE

    4 publications · 232 citations

    4

    h-index

  3. RNA

    4 publications · 1.1K citations

    4

    h-index

  4. RNA Biology

    4 publications · 116 citations

    4

    h-index

  5. Scientific Reports

    3 publications · 180 citations

    3

    h-index

1–5