Concepedia

Scaffold Rigidity Modulation

Scaffold Rigidity Modulation is a computational strategy in scaffold hopping that systematically alters the conformational flexibility of molecular frameworks to optimize structural adaptability while preserving desired pharmacological activity.

18

Publications

670

Citations

101

Authors

37

Institutions

Publications per year

2017–2026

8

Parents

Publications

18

Pyrrolinone-Based Peptidomimetics.“<i>Let the Enzyme or Receptor be the Judge</i>”

Amos B. Smith, Adam K. Charnley, Ralph Hirschmann · Accounts of Chemical Research · 2010 · 95 citations · Full text

, , +16

Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences

Stefanie Dobitz, Matthew R. Aronoff, Helma Wennemers · Accounts of Chemical Research · 2017 · 71 citations

, , +16

Exocyclic Control of Turn Induction in Macrocyclic Peptide Scaffolds

Serge Zaretsky, Conor C. G. Scully, Alan J. Lough et al. · Chemistry - A European Journal · 2013 · 59 citations

, , +15

Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations

Giovanni Chillemi, Ilda D’Annessa, P Fiorani et al. · Nucleic Acids Research · 2008 · 55 citations · Full text

, , +15

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

Shashwati Paul, Daniel Adelfinsky, Christophe Salomé et al. · Chemical Science · 2023 · 46 citations · Full text

, , +17

1–5 of 18

Authors

101

  1. MR
    Matthew R. Aronoff

    University of Wisconsin–Madison, United States

    1 publications · 71 citations

    1

    h-index

  2. AJ
    Alan J. Lough

    University of Toronto, Canada

    1 publications · 59 citations

    1

    h-index

  3. ER
    Eli Roubini

    Hebrew University of Jerusalem, Israel

    1 publications · 11 citations

    1

    h-index

  4. LW
    Lewis Whitehead

    Novartis (Switzerland), Switzerland

    1 publications · 35 citations

    1

    h-index

  5. MK
    M. Kevin Brown

    Indiana University Bloomington, United States

    1 publications · 46 citations

    1

    h-index

1–5 of 101

Institutions

37

  1. École Normale Supérieure - PSL

    Paris, France

    1 h-index

    1 publications

    18 citations

  2. Harbin Institute of Technology

    Harbin, China

    1 h-index

    2 publications

    74 citations

  3. National Environmental Engineering Research Institute

    Nagpur, India

    1 h-index

    2 publications

    24 citations

  4. Université de Haute-Alsace

    Mulhouse, France

    1 h-index

    1 publications

    40 citations

  5. Beijing Institute of Technology

    Beijing, China

    1 h-index

    2 publications

    44 citations

  6. Consortium GARR

    Rome, Italy

    1 h-index

    1 publications

    55 citations

  7. National Eye Institute

    Bethesda, United States

    1 h-index

    1 publications

    42 citations

  8. Université de Lille

    Lille, France

    1 h-index

    5 publications

    90 citations

1–8 of 37

Venues

  1. Accounts of Chemical Research

    2 publications · 166 citations

    2

    h-index

  2. Journal of Medicinal Chemistry

    2 publications · 55 citations

    2

    h-index

  3. Chemical Science

    1 publications · 46 citations

    1

    h-index

  4. ACS Applied Bio Materials

    AABM · 1 publications · 37 citations

    1

    h-index

  5. Journal of Controlled Release

    1 publications · 18 citations

    1

    h-index

1–5