Rodent models is the academic and methodological concept centered on employing specific rodent species, primarily mice and rats, as biological surrogates to investigate fundamental biological processes, disease mechanisms, and the efficacy and safety of potential therapeutic agents. This approach is significant due to the rodents' genetic manipulability, relatively short life cycles, and physiological similarities to humans in many systems, rendering them indispensable platforms for preclinical research and hypothesis testing in biomedicine.