Concepedia

Replication-associated Mutagenesis

Replication-Associated Mutagenesis is a molecular mechanism in the context of somatic hypermutation that refers to the introduction of mutations during DNA replication, distinguished by its dependence on the replication process and associated polymerase errors or lesion bypass in immunoglobulin genes.

125

Publications

6.9K

Citations

467

Authors

179

Institutions

Publications per year

2017–2026

11

Parents

Publications

125

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

James I. Hoopes, Luis M. Cortez, Tony M. Mertz et al. · Cell Reports · 2016 · 229 citations · Full text

, , +15

The Hydantoin Lesions Formed from Oxidation of 7,8-Dihydro-8-oxoguanine Are Potent Sources of Replication Errors in Vivo

Paul T. Henderson, James C. Delaney, James G. Muller et al. · Biochemistry · 2003 · 216 citations

, , +17

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

Vinay K. Pathak, Howard M. Temin · Proceedings of the National Academy of Sciences · 1990 · 213 citations

, , +14

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

Jacob G. Jansen, Petra Langerak, Anastasia Tsaalbi‐Shtylik et al. · The Journal of Experimental Medicine · 2006 · 206 citations · Full text

, , +14

Human and mouse homologs of <i>Escherichia coli</i> DinB (DNA polymerase IV), members of the UmuC/DinB superfamily

Valerie L. Gerlach, L. Aravind, Garrett Gotway et al. · Proceedings of the National Academy of Sciences · 1999 · 188 citations · Full text

, , +14

1–5 of 125

Authors

467

  1. SP
    Satya Prakash

    The University of Texas Medical Branch at Galveston, United States

    4 publications · 247 citations

    4

    h-index

  2. LP
    Louise Prakash

    The University of Texas Medical Branch at Galveston, United States

    4 publications · 247 citations

    4

    h-index

  3. TA
    Thomas A. Kunkel

    National Institute of Environmental Health Sciences, United States

    4 publications · 451 citations

    4

    h-index

  4. SJ
    Sue Jinks-Robertson

    Emory University, United States

    4 publications · 187 citations

    4

    h-index

  5. MY
    Masami Yamada

    National Institute of Health Sciences, Japan

    3 publications · 61 citations

    3

    h-index

1–5 of 467

Institutions

179

  1. National Institute of Environmental Health Sciences

    Durham, United States

    7 h-index

    13 publications

    970 citations

  2. National Institutes of Health

    Bethesda, United States

    6 h-index

    20 publications

    2K citations

  3. Duke Medical Center

    Durham, United States

    4 h-index

    7 publications

    353 citations

  4. Stanford University

    Stanford, United States

    4 h-index

    15 publications

    1.4K citations

  5. Duke University Hospital

    Durham, United States

    4 h-index

    7 publications

    353 citations

  6. Johns Hopkins University

    Baltimore, United States

    4 h-index

    6 publications

    170 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    11 publications

    1.7K citations

  8. Oak Ridge National Laboratory

    Oak Ridge, United States

    3 h-index

    8 publications

    379 citations

1–8 of 179

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 1.5K citations

    17

    h-index

  2. Nucleic Acids Research

    9 publications · 393 citations

    9

    h-index

  3. Biochemistry

    8 publications · 444 citations

    8

    h-index

  4. Journal of Biological Chemistry

    JBC · 8 publications · 481 citations

    8

    h-index

  5. Genetics

    7 publications · 196 citations

    7

    h-index

1–5