Concepedia

Regulatory Sequence Design

Regulatory Sequence Design is a computational and experimental methodology within synthetic gene design that specifies the construction of DNA sequences controlling gene expression levels and patterns by uniquely integrating promoter, enhancer, and repressor elements to achieve targeted transcriptional regulation.

23

Publications

1.8K

Citations

152

Authors

74

Institutions

Publications per year

2017–2026

9

Parents

Publications

23

Toehold Switches: De-Novo-Designed Regulators of Gene Expression

Alexander A. Green, Pamela A. Silver, James J. Collins et al. · Cell · 2014 · 841 citations · Full text

, , +16

A Human T-Cell Leukemia Virus Type 1 Regulatory Element Enhances the Immunogenicity of Human Immunodeficiency Virus Type 1 DNA Vaccines in Mice and Nonhuman Primates

Dan H. Barouch, Zhi-Yong Yang, Wing-Pui Kong et al. · Journal of Virology · 2005 · 166 citations · Full text

, , +17

Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacterial and Mammalian Cells via Dynamic RNA Nanotechnology

Mikhail Hanewich-Hollatz, Zhewei Chen, Lisa M. Hochrein et al. · ACS Central Science · 2019 · 117 citations · Full text

, , +17

EXPRESSION OF α 2 -ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α 2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS

R. Wang, Leigh B. MacMillan, Robert T. Fremeau et al. · Neuroscience · 1996 · 116 citations

, , +14

Controlling gene expression with deep generative design of regulatory DNA

Jan Zrimec, Xiaozhi Fu, Azam Sheikh Muhammad et al. · Nature Communications · 2022 · 100 citations · Full text

, , +11

1–5 of 23

Authors

152

  1. HE
    Hanneke Evens

    KU Leuven, Belgium

    1 publications · 81 citations

    1

    h-index

  2. FA
    Frans A. Krens

    Wageningen University & Research, Netherlands

    1 publications · 15 citations

    1

    h-index

  3. TH
    T. H. Li

    China Agricultural University, China

    1 publications · 28 citations

    1

    h-index

  4. NB
    Nariman Battulin

    Institute of Cytology and Genetics, Russia

    1 publications · 13 citations

    1

    h-index

  5. JZ
    Jianing Zhang

    Sun Yat-sen University, China

    1 publications · 21 citations

    1

    h-index

1–5 of 152

Institutions

74

  1. Harvard University

    Cambridge, United States

    4 h-index

    17 publications

    4.8K citations

  2. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    14 publications

    442 citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    859 citations

  4. Broad Institute

    Cambridge, United States

    2 h-index

    5 publications

    158 citations

  5. Ghent University

    Ghent, Belgium

    2 h-index

    5 publications

    193 citations

  6. National Institutes of Health

    Bethesda, United States

    2 h-index

    5 publications

    692 citations

  7. Johns Hopkins University

    Baltimore, United States

    1 h-index

    1 publications

    35 citations

  8. Wageningen University & Research

    Wageningen, The Netherlands

    1 h-index

    3 publications

    45 citations

1–8 of 74

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 65 citations

    3

    h-index

  2. BMC Research Notes

    1 publications · 31 citations

    1

    h-index

  3. Plant Molecular Biology

    1 publications · 41 citations

    1

    h-index

  4. PLoS ONE

    1 publications · 59 citations

    1

    h-index

  5. Cell

    1 publications · 841 citations

    1

    h-index

1–5