Concepedia

Receptor Inactivation

Receptor Inactivation is a biochemical process whereby a drug receptor loses its ability to initiate a cellular response following ligand binding, typically due to conformational change, covalent modification, internalization, or degradation.

223

Publications

15.1K

Citations

886

Authors

319

Institutions

Publications per year

2017–2026

11

Parents

Publications

223

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

, , +17

Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors

Kevin D. Burris, Thaddeus F. Molski, Cen Xu et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 922 citations

, , +16

Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

Jiang‐Fan Chen, Kui Xu, Jacobus P. Petzer et al. · PubMed · 2001 · 509 citations · Full text

, , +17

Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

Kung Meng, Angeles Rodríguez‐Peña, Todor Dimitrov et al. · Proceedings of the National Academy of Sciences · 2000 · 415 citations

, , +17

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

Tomoya Hino, T. Arakawa, Hiroko Iwanari et al. · Nature · 2012 · 295 citations

, , +14

1–5 of 223

Authors

886

  1. EM
    Emanuel Meller

    New York University, United States

    6 publications · 385 citations

    6

    h-index

  2. PH
    Paul H. Weigel

    University of Oklahoma Health Sciences Center, United States

    6 publications · 122 citations

    6

    h-index

  3. VP
    Victoria P. Knutson

    The University of Texas Health Science Center at Houston, United States

    5 publications · 345 citations

    5

    h-index

  4. CA
    Cynthia A. Crawford

    California State University, San Bernardino, United States

    4 publications · 67 citations

    4

    h-index

  5. FJ
    Frederick J. Ehlert

    University of California, Irvine, United States

    4 publications · 173 citations

    4

    h-index

1–5 of 886

Institutions

319

  1. University of California, San Francisco

    San Francisco, United States

    9 h-index

    31 publications

    3K citations

  2. Johns Hopkins University

    Baltimore, United States

    8 h-index

    19 publications

    1.9K citations

  3. New York University

    New York, United States

    6 h-index

    15 publications

    895 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    18 publications

    2.6K citations

  5. Harvard University

    Cambridge, United States

    6 h-index

    17 publications

    2.3K citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    5 h-index

    12 publications

    237 citations

  7. Massachusetts General Hospital

    Boston, United States

    5 h-index

    14 publications

    2.5K citations

  8. Cornell University

    Ithaca, United States

    5 h-index

    12 publications

    753 citations

1–8 of 319

Venues

  1. Journal of Biological Chemistry

    JBC · 26 publications · 1.9K citations

    22

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.8K citations

    16

    h-index

  3. Molecular Pharmacology

    17 publications · 936 citations

    16

    h-index

  4. 16

    h-index

  5. Journal of Neuroscience

    10 publications · 809 citations

    10

    h-index

1–5