Concepedia

Purifying Selection Analysis

Purifying Selection Analysis is a computational genomics method that identifies evolutionary constraints by detecting the reduced frequency of deleterious mutations in functional genomic elements, distinguishing it from other selection analyses through its focus on the removal of harmful variants rather than the promotion of advantageous ones.

223

Publications

13.9K

Citations

1.5K

Authors

543

Institutions

Publications per year

2017–2026

98

Parents

Publications

223

Distribution and intensity of constraint in mammalian genomic sequence

Gregory M. Cooper, Eric A. Stone, George Asimenos et al. · Genome Research · 2005 · 1.4K citations · Full text

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Emergence of SARS-CoV-2 through recombination and strong purifying selection

Xiaojun Li, Elena E. Giorgi, Manukumar Honnayakanahalli Marichannegowda et al. · Science Advances · 2020 · 424 citations · Full text

, , +16

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

Luis B. Barreiro, Meriem Ben‐Ali, Hélène Quach et al. · PLoS Genetics · 2009 · 402 citations · Full text

, , +17

De novo rates and selection of large copy number variation

Andy Itsara, Hao Wu, Joshua D. Smith et al. · Genome Research · 2010 · 337 citations · Full text

, , +16

A map of constrained coding regions in the human genome

James M. Havrilla, Brent S. Pedersen, Ryan M. Layer et al. · Nature Genetics · 2018 · 284 citations · Full text

, , +17

1–5 of 223

Authors

1.5K

  1. LD
    Laurence D. Hurst

    University of Bath, United Kingdom

    3 publications · 176 citations

    3

    h-index

  2. YZ
    Yi Zhang

    Wuhan University, China

    2 publications · 184 citations

    2

    h-index

  3. CX
    Chuan Xiao

    China North Industries Group Corporation (China), China

    2 publications · 538 citations

    2

    h-index

  4. CS
    Caitlin S. Pepperell

    University of Wisconsin–Madison, United States

    2 publications · 171 citations

    2

    h-index

  5. JP
    Jiaofeng Peng

    Shenzhen University, China

    2 publications · 36 citations

    2

    h-index

1–5 of 1.5K

Institutions

543

  1. Chinese Academy of Sciences

    Beijing, China

    14 h-index

    69 publications

    2.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    42 publications

    5.8K citations

  3. Northwest A&F University

    Yangling, China

    7 h-index

    45 publications

    2.3K citations

  4. National Institutes of Health

    Bethesda, United States

    7 h-index

    18 publications

    3.3K citations

  5. Stanford University

    Stanford, United States

    6 h-index

    16 publications

    5.6K citations

  6. Institute of Genetics and Developmental Biology

    Beijing, China

    6 h-index

    31 publications

    1.1K citations

  7. Inserm

    Paris, France

    5 h-index

    12 publications

    2K citations

  8. Harvard University

    Cambridge, United States

    5 h-index

    11 publications

    408 citations

1–8 of 543

Venues

  1. Molecular Biology and Evolution

    MBE · 19 publications · 1.4K citations

    17

    h-index

  2. PLoS ONE

    18 publications · 783 citations

    16

    h-index

  3. BMC Evolutionary Biology

    11 publications · 345 citations

    11

    h-index

  4. Frontiers in Plant Science

    10 publications · 407 citations

    9

    h-index

  5. Genome Biology and Evolution

    GBE · 8 publications · 289 citations

    8

    h-index

1–5