Concepedia

Protein Optimization

Protein Optimization is a methodological framework within computational biology that refines protein sequences or structures to enhance specific functional properties, distinguished from related approaches by its focus on improving predefined performance metrics such as stability, activity, or expressibility through algorithmic or experimental design strategies.

176

Publications

11.2K

Citations

765

Authors

312

Institutions

Publications per year

2017–2026

54

Parents

Publications

176

Thermofluor-based high-throughput stability optimization of proteins for structural studies

U.B. Ericsson, B.M. Hallberg, George T. DeTitta et al. · Analytical Biochemistry · 2006 · 843 citations

, , +10

Optimality and evolutionary tuning of the expression level of a protein

E. Dekel, Uri Alon · Nature · 2005 · 833 citations

, , +14

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Peter J. Chen, Jeffrey A. Hussmann, Jun Yan et al. · Cell · 2021 · 799 citations · Full text

, , +13

Low-N protein engineering with data-efficient deep learning

Surojit Biswas, Grigory Khimulya, Ethan C. Alley et al. · Nature Methods · 2021 · 417 citations

, , +14

A set of BEST triple-resonance experiments for time-optimized protein resonance assignment

Ewen Lescop, Paul Schanda, Bernhard Brutscher · Journal of Magnetic Resonance · 2007 · 373 citations

, , +4

1–5 of 176

Authors

765

  1. CB
    Chris Bailey‐Kellogg

    Dartmouth College, United States

    7 publications · 209 citations

    7

    h-index

  2. KE
    Karl E. Griswold

    Dartmouth College, United States

    4 publications · 144 citations

    4

    h-index

  3. DB
    David Baker

    University of Washington, United States

    4 publications · 602 citations

    4

    h-index

  4. TS
    Thomas Schiex

    Centre National de la Recherche Scientifique, France

    3 publications · 182 citations

    3

    h-index

  5. AS
    Andrew S. Parker

    Dartmouth College, United States

    3 publications · 107 citations

    3

    h-index

1–5 of 765

Institutions

312

  1. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    26 publications

    1.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    21 publications

    6.8K citations

  3. University of Washington

    Seattle, United States

    7 h-index

    35 publications

    4.9K citations

  4. Dartmouth College

    Hanover, United States

    7 h-index

    22 publications

    706 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    16 publications

    3K citations

  6. Pennsylvania State University

    State College, United States

    5 h-index

    21 publications

    2.1K citations

  7. California Institute of Technology

    Pasadena, United States

    5 h-index

    13 publications

    678 citations

  8. Harvard University

    Cambridge, United States

    5 h-index

    11 publications

    4.6K citations

1–8 of 312

Venues

  1. Journal of Computational Chemistry

    9 publications · 283 citations

    9

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 8 publications · 209 citations

    8

    h-index

  3. The Journal of Chemical Physics

    6 publications · 151 citations

    6

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 392 citations

    5

    h-index

  5. Protein Expression and Purification

    5 publications · 109 citations

    5

    h-index

1–5