Concepedia

Protein Design Algorithms

Protein Design Algorithms is a computational methodology that systematically identifies amino acid sequences and three-dimensional conformations to achieve desired protein structures and functions, distinguished from other algorithmic approaches by its focus on de novo design, optimization, and engineering of proteins with specific biophysical properties.

283

Publications

22.9K

Citations

1K

Authors

320

Institutions

Publications per year

2017–2026

88

Parents

Publications

283

Robust deep learning–based protein sequence design using ProteinMPNN

Justas Dauparas, Ivan Anishchenko, Nathaniel R. Bennett et al. · Science · 2022 · 1.9K citations · Full text

, , +14

De Novo Computational Design of Retro-Aldol Enzymes

Lin Jiang, Eric A. Althoff, Fernando R. Clemente et al. · Science · 2008 · 1.2K citations

, , +17

De Novo Protein Design: Fully Automated Sequence Selection

Bassil I. Dahiyat, Stephen L. Mayo · Science · 1997 · 1.2K citations

, , +15

PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta

Sidhartha Chaudhury, Sergey Lyskov, Jeffrey J. Gray · Bioinformatics · 2010 · 909 citations · Full text

, , +17

Computational design of receptor and sensor proteins with novel functions

Loren L. Looger, Mary A. Dwyer, James J. Smith et al. · Nature · 2003 · 667 citations

, , +16

1–5 of 283

Authors

1K

  1. DB
    David Baker

    University of Washington, United States

    26 publications · 6.6K citations

    22

    h-index

  2. BR
    Bruce R. Donald

    Duke University, United States

    21 publications · 1.1K citations

    18

    h-index

  3. SL
    Stephen L. Mayo

    California Institute of Technology, United States

    14 publications · 2.5K citations

    14

    h-index

  4. BK
    Brian Kuhlman

    University of North Carolina at Chapel Hill, United States

    9 publications · 1.1K citations

    9

    h-index

  5. PH
    Po‐Ssu Huang

    Stanford University, United States

    8 publications · 831 citations

    8

    h-index

1–5 of 1K

Institutions

320

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    31 h-index

    72 publications

    32.8K citations

  2. University of Washington

    Seattle, United States

    23 h-index

    254 publications

    91.9K citations

  3. Duke Medical Center

    Durham, United States

    16 h-index

    44 publications

    4.7K citations

  4. California Institute of Technology

    Pasadena, United States

    16 h-index

    49 publications

    6.7K citations

  5. Duke University

    Durham, United States

    15 h-index

    58 publications

    3.2K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    51 publications

    1.7K citations

  7. Duke University Hospital

    Durham, United States

    13 h-index

    36 publications

    4.4K citations

  8. Pennsylvania State University

    State College, United States

    10 h-index

    25 publications

    1.1K citations

1–8 of 320

Venues

  1. Bioinformatics

    19 publications · 1.8K citations

    18

    h-index

  2. Journal of Computational Chemistry

    21 publications · 966 citations

    18

    h-index

  3. Protein Science

    PS · 14 publications · 1.1K citations

    14

    h-index

  4. Journal of Molecular Biology

    JMB · 14 publications · 1.2K citations

    14

    h-index

  5. Proteins Structure Function and Bioinformatics

    17 publications · 578 citations

    14

    h-index

1–5