Concepedia

Protein Denaturation

Protein Denaturation is the process by which a protein loses its native three-dimensional structure due to the disruption of non-covalent interactions and disulfide bonds, resulting in the loss of biological activity without cleavage of peptide bonds.

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3.2K

Some Factors in the Interpretation of Protein Denaturation

W. Kauzmann · Advances in protein chemistry · 1959 · 4.9K citations

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Denaturant <i>m</i> values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding

Jeffrey K. Myers, C. Nick Pace, J. Martin Scholtz · Protein Science · 1995 · 1.7K citations · Full text

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Protein denaturation. C. Theoretical models for the mechanism of denaturation.

Charles Tanford · PubMed · 1970 · 1.6K citations

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Are there pathways for protein folding?

Cyrus Levinthal · Journal de Chimie Physique · 1968 · 1.5K citations

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Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

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Authors

9K

  1. FA
    Faizan Ahmad

    Jamia Millia Islamia, India

    23 publications · 761 citations

    19

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  2. YG
    Yuji Goto

    The University of Osaka, Japan

    21 publications · 1.3K citations

    17

    h-index

  3. JF
    John F. Carpenter

    University of Colorado Boulder, United States

    16 publications · 3.5K citations

    16

    h-index

  4. JC
    Jui‐Yoa Chang

    Novartis (Switzerland), Switzerland

    18 publications · 574 citations

    16

    h-index

  5. DP
    Daniel P. Raleigh

    Stony Brook University, United States

    17 publications · 768 citations

    16

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Institutions

1.9K

  1. Centre National de la Recherche Scientifique

    Paris, France

    31 h-index

    176 publications

    11.9K citations

  2. National Institutes of Health

    Bethesda, United States

    30 h-index

    103 publications

    10.7K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    30 h-index

    98 publications

    11.9K citations

  4. Cornell University

    Ithaca, United States

    29 h-index

    119 publications

    7.7K citations

  5. Harvard University

    Cambridge, United States

    26 h-index

    93 publications

    10K citations

  6. University of Cambridge

    Cambridge, United Kingdom

    25 h-index

    100 publications

    12.7K citations

  7. Johns Hopkins University

    Baltimore, United States

    24 h-index

    74 publications

    8.1K citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    23 h-index

    101 publications

    5.4K citations

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  1. Journal of Biological Chemistry

    JBC · 207 publications · 18.7K citations

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  2. Biochemistry

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    70

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  3. Proceedings of the National Academy of Sciences

    PNAS · 92 publications · 14.5K citations

    63

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  4. Journal of Molecular Biology

    JMB · 97 publications · 10.4K citations

    55

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  5. Journal of the American Chemical Society

    JACS · 74 publications · 7.6K citations

    44

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