Concepedia

Aggregation During Denaturation

Aggregation During Denaturation is a phenomenon in protein chemistry whereby partially unfolded or denatured polypeptide chains associate into insoluble, non-native assemblies due to exposed hydrophobic regions that are normally buried in the native structure.

118

Publications

6.7K

Citations

392

Authors

154

Institutions

Publications per year

2017–2026

13

Parents

Publications

118

Use of fast protein size-exclusion liquid chromatography to study the unfolding of proteins which denature through the molten globule

Vladimir N. Uversky · Biochemistry · 1993 · 437 citations

, , +12

A kinetic study of the competition between renaturation and aggregation during the refolding of denatured-reduced egg white lysozyme

Michel Goldberg, Rainer Rudolph, Rainer Jaenicke · Biochemistry · 1991 · 393 citations

, , +9

Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition

Margaret A. Speed, Daniel I. C. Wang, Jonathan King · Nature Biotechnology · 1996 · 311 citations

, , +17

Aqueous Urea Solutions:  Structure, Energetics, and Urea Aggregation

Martin C. Stumpe, Helmut Grubmüller · The Journal of Physical Chemistry B · 2007 · 235 citations · Full text

, , +17

Mechanism of insulin aggregation and stabilization in agitated aqueous solutions

Victoria Sluzky, Alexander M. Klibanov, Róbert Langer · Biotechnology and Bioengineering · 1992 · 200 citations

, , +15

1–5 of 118

Authors

392

  1. JA
    Julius A. Gordon

    University of Colorado Denver, United States

    3 publications · 105 citations

    3

    h-index

  2. DI
    Daniel I. C. Wang

    Massachusetts Institute of Technology, United States

    3 publications · 448 citations

    3

    h-index

  3. VD
    Verne D. Hospelhorn

    University of Chicago, United States

    2 publications · 72 citations

    2

    h-index

  4. TC
    Thomas Croguennec

    Institut Agro Rennes-Angers, France

    2 publications · 157 citations

    2

    h-index

  5. EV
    Elwood V. Jensen

    University of Chicago, United States

    2 publications · 72 citations

    2

    h-index

1–5 of 392

Institutions

154

  1. Massachusetts Institute of Technology

    Cambridge, United States

    4 h-index

    12 publications

    1.9K citations

  2. Université Paris Cité

    Paris, France

    3 h-index

    4 publications

    121 citations

  3. University of Delaware

    Newark, United States

    3 h-index

    8 publications

    698 citations

  4. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    5 publications

    412 citations

  5. University of Colorado Denver

    Denver, United States

    3 h-index

    6 publications

    210 citations

  6. Institute of Agrobiological Sciences

    Tsukuba, Japan

    2 h-index

    4 publications

    216 citations

  7. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    4 publications

    87 citations

  8. Kyushu University

    Fukuoka, Japan

    2 h-index

    4 publications

    89 citations

1–8 of 154

Venues

  1. Biochemistry

    7 publications · 1K citations

    7

    h-index

  2. Journal of the American Chemical Society

    JACS · 6 publications · 533 citations

    6

    h-index

  3. Journal of Molecular Biology

    JMB · 6 publications · 234 citations

    6

    h-index

  4. FEBS Letters

    4 publications · 110 citations

    4

    h-index

  5. Food Hydrocolloids

    4 publications · 144 citations

    4

    h-index

1–5