Concepedia

Protein Backbone Design

Protein Backbone Design is a computational method in protein engineering that specifically generates or optimizes the three-dimensional conformation of a protein’s polypeptide backbone without immediate consideration of side-chain identities, distinguishing it from full-atom protein design approaches.

134

Publications

9.3K

Citations

623

Authors

222

Institutions

Publications per year

2017–2026

46

Parents

Publications

134

Native protein sequences are close to optimal for their structures

Brian Kuhlman, David Baker · Proceedings of the National Academy of Sciences · 2000 · 831 citations

, , +14

Designing a 20-residue protein

Jonathan W. Neidigh, R. Matthew Fesinmeyer, Niels H. Andersen · Nature Structural Biology · 2002 · 797 citations

, , +10

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

Po‐Ssu Huang, Yih‐En Andrew Ban, Florian Richter et al. · PLoS ONE · 2011 · 414 citations · Full text

, , +16

A Pareto-Optimal Refinement Method for Protein Design Scaffolds

Lucas G. Nivón, Rocco Moretti, David Baker · PLoS ONE · 2013 · 331 citations · Full text

, , +16

High thermodynamic stability of parametrically designed helical bundles

Po‐Ssu Huang, Gustav Oberdorfer, Chunfu Xu et al. · Science · 2014 · 300 citations · Full text

, , +17

1–5 of 134

Authors

623

  1. DB
    David Baker

    University of Washington, United States

    17 publications · 3K citations

    16

    h-index

  2. TK
    Tanja Kortemme

    University of California, San Francisco, United States

    9 publications · 508 citations

    9

    h-index

  3. BK
    Brian Kuhlman

    University of North Carolina at Chapel Hill, United States

    8 publications · 1.3K citations

    8

    h-index

  4. PH
    Po‐Ssu Huang

    Stanford University, United States

    6 publications · 1.1K citations

    6

    h-index

  5. MO
    Markus O. Zimmermann

    University of Tübingen, Germany

    4 publications · 186 citations

    4

    h-index

1–5 of 623

Institutions

222

  1. University of Washington

    Seattle, United States

    18 h-index

    124 publications

    18.8K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    32 publications

    5K citations

  3. University of California, San Francisco

    San Francisco, United States

    10 h-index

    27 publications

    1.2K citations

  4. QB3

    San Francisco, United States

    8 h-index

    12 publications

    584 citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    8 h-index

    26 publications

    1.4K citations

  6. Stanford University

    Stanford, United States

    7 h-index

    16 publications

    1.3K citations

  7. New York University

    New York, United States

    6 h-index

    21 publications

    1.7K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    11 publications

    827 citations

1–8 of 222

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 1.4K citations

    9

    h-index

  2. PLoS ONE

    8 publications · 1.1K citations

    8

    h-index

  3. Protein Science

    PS · 7 publications · 306 citations

    7

    h-index

  4. Journal of Molecular Biology

    JMB · 7 publications · 464 citations

    7

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 7 publications · 528 citations

    7

    h-index

1–5