Concepedia

Protease-triggered Activation

Protease-Triggered Activation is a prodrug activation mechanism in which enzymatic cleavage by specific proteases selectively releases the active pharmacological agent from its inactive precursor form, distinguishing it from other activation pathways through its reliance on proteolytic reactivity as the triggering event.

125

Publications

12.6K

Citations

661

Authors

214

Institutions

Publications per year

2017–2026

20

Parents

Publications

125

Cell entry mechanisms of SARS-CoV-2

Jian Shang, Yushun Wan, Chuming Luo et al. · Proceedings of the National Academy of Sciences · 2020 · 3.5K citations · Full text

, , +17

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

Gabriel Sollberger, Axel Choidas, Garth L. Burn et al. · Science Immunology · 2018 · 737 citations

, , +14

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

Alison J. Darmon, Donald W. Nicholson, R. Chris Bleackley · Nature · 1995 · 723 citations

, , +14

PDGF-C is a new protease-activated ligand for the PDGF α-receptor

Xuri Li, Annica Pontén, Karin Aase et al. · Nature Cell Biology · 2000 · 619 citations

, , +10

Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production

Henk F. Kauffman, J F Tomee, Marjolein A. van de Riet et al. · Journal of Allergy and Clinical Immunology · 2000 · 365 citations · Full text

, , +17

1–5 of 125

Authors

661

  1. MM
    Markus M. Lerch

    Universitätsmedizin Greifswald, Germany

    3 publications · 123 citations

    3

    h-index

  2. MA
    María A. Juliano

    Universidade Federal de São Paulo, Brazil

    3 publications · 81 citations

    3

    h-index

  3. AS
    Andreas S. Baur

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    2 publications · 130 citations

    2

    h-index

  4. TH
    Thomas Harrer

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    2 publications · 130 citations

    2

    h-index

  5. GF
    Gabriele Fluhr

    Universitätsmedizin Greifswald, Germany

    2 publications · 53 citations

    2

    h-index

1–5 of 661

Institutions

214

  1. Yale University

    New Haven, United States

    5 h-index

    18 publications

    454 citations

  2. National Institutes of Health

    Bethesda, United States

    5 h-index

    18 publications

    715 citations

  3. University of Würzburg

    Würzburg, Germany

    4 h-index

    11 publications

    253 citations

  4. Rockefeller University

    New York, United States

    4 h-index

    12 publications

    752 citations

  5. Lund University

    Lund, Sweden

    4 h-index

    11 publications

    496 citations

  6. Stanford University

    Stanford, United States

    3 h-index

    8 publications

    792 citations

  7. University of California, Riverside

    Riverside, United States

    3 h-index

    12 publications

    414 citations

  8. Max Planck Institute of Biochemistry

    Martinsried, Germany

    3 h-index

    10 publications

    2.9K citations

1–8 of 214

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 782 citations

    8

    h-index

  2. PubMed

    Repository · 6 publications · 280 citations

    6

    h-index

  3. Experimental Cell Research

    ECR · 4 publications · 166 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 3.8K citations

    4

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 3 publications · 71 citations

    3

    h-index

1–5