Concepedia

Prodrug Selectivity

Prodrug Selectivity is a pharmacological property that denotes the preferential activation or conversion of a prodrug into its active metabolite at the target site or within the target population, distinguishing it from non-selective prodrug activation by virtue of its spatial, temporal, or biochemical specificity.

143

Publications

6.3K

Citations

886

Authors

222

Institutions

Publications per year

2017–2026

31

Parents

Publications

143

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, C A Richards et al. · Proceedings of the National Academy of Sciences · 1994 · 422 citations

, , +17

An Activatable Prodrug for the Treatment of Metastatic Tumors

Eun Joong Kim, Sankarprasad Bhuniya, Hyunseung Lee et al. · Journal of the American Chemical Society · 2014 · 265 citations

, , +17

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, Steven S. Good et al. · PubMed · 1993 · 230 citations

, , +13

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

Tobias Klein, Daniela Abgottspon, Matthias Wittwer et al. · Journal of Medicinal Chemistry · 2010 · 199 citations · Full text

, , +15

Single‐Triggered Trimeric Prodrugs

Keren Haba, Mikhail Popkov, Marina Shamis et al. · Angewandte Chemie International Edition · 2005 · 158 citations · Full text

, , +12

1–5 of 143

Authors

886

  1. AN
    Abraham Nudelman

    Bar-Ilan University, Israel

    4 publications · 156 citations

    4

    h-index

  2. SR
    Steve R. Roffler

    Institute of Biomedical Sciences, Academia Sinica, Taiwan

    4 publications · 136 citations

    4

    h-index

  3. AR
    Ada Rephaeli

    Bar-Ilan University, Israel

    4 publications · 156 citations

    4

    h-index

  4. KB
    Kenneth B. Sloan

    University of Florida, United States

    3 publications · 40 citations

    3

    h-index

  5. PM
    Pavel Majer

    Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Czechia

    3 publications · 124 citations

    3

    h-index

1–5 of 886

Institutions

222

  1. Tel Aviv University

    Tel Aviv, Israel

    5 h-index

    18 publications

    1K citations

  2. University of Kansas

    Lawrence, United States

    4 h-index

    13 publications

    389 citations

  3. University of Michigan

    Ann Arbor, United States

    4 h-index

    15 publications

    310 citations

  4. Scripps Research Institute

    San Diego, United States

    4 h-index

    15 publications

    921 citations

  5. Johns Hopkins University

    Baltimore, United States

    4 h-index

    32 publications

    1.4K citations

  6. Chia Nan University of Pharmacy and Science

    Tainan City, Taiwan

    3 h-index

    15 publications

    415 citations

  7. University of Oxford

    Oxford, United Kingdom

    3 h-index

    6 publications

    325 citations

  8. Rega Institute for Medical Research

    Leuven, Belgium

    3 h-index

    4 publications

    330 citations

1–8 of 222

Venues

  1. Journal of Medicinal Chemistry

    28 publications · 1.6K citations

    24

    h-index

  2. PubMed

    Repository · 11 publications · 715 citations

    11

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    8 publications · 243 citations

    8

    h-index

  4. Molecules

    6 publications · 92 citations

    6

    h-index

  5. Journal of Pharmaceutical Sciences

    6 publications · 142 citations

    6

    h-index

1–5