C A Richards

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, C A Richards et al. · Proceedings of the National Academy of Sciences · 1994 · 420 citations · Full text

Cytosine Deaminase, Immunology, Cancer Biology +18

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

Brian E. Huber, C A Richards, Thomas A. Krenitsky · Proceedings of the National Academy of Sciences · 1991 · 314 citations · Full text

Viral Replication, Synthetic Virology, Immunology +19

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

M H St Clair, C A Richards, T Spector et al. · Antimicrobial Agents and Chemotherapy · 1987 · 279 citations · Full text

Immunology, Molecular Biology, Antiviral Drug +16

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, Steven S. Good et al. · PubMed · 1993 · 230 citations

Widr Cells, Cytosine Deaminase, Chemoprevention Strategy +15

Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.

Richard B. Gayle, C R Maliszewski, Steven D. Gimpel et al. · Journal of Clinical Investigation · 1998 · 188 citations · Full text

Platelet Biology, Thrombosis, Inflammation +14