FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

Tobias Klein, Daniela Abgottspon, Matthias Wittwer, +13

Journal of Medicinal Chemistry

Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution

Hemanshu Mundhada, Jose Miguel Seoane, Konstantin Schneider, +7

Metabolic Engineering

BiologyBiosynthesisAdaptive Laboratory EvolutionBiochemistryBioenergetics +9

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

Kanchana Rueksomtawin Kildegaard, Niels Bjerg Jensen, Konstantin Schneider, +13

Microbial Cell Factories

Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

Julie A. Tucker, Tobias Klein, J. Breed, +4

Structure

Protein FunctionSignaling PathwayStructural InsightsReceptor Tyrosine KinaseMolecular Biology +6

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Matthias Negri, +8

Journal of Medicinal Chemistry

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Tobias Klein, Navratna Vajpai, Jonathan J. Phillips, +10

Nature Communications

Identification of Small-Molecule Antagonists of the <i>Pseudomonas aeruginosa</i> Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization

Tobias Klein, Claudia Henn, Johannes C. de Jong, +7

ACS Chemical Biology

Drug TargetMicrobial PathogensPqsr BindersMolecular BiologyBacterial Pathogens +16

Multilayer Coating of Gold Nanoparticles with Drug−Polymer Coadsorbates

Nico Reum, Claudia Fink‐Straube, Tobias Klein, +3

Langmuir

Discovery and Biophysical Characterization of 2-Amino-oxadiazoles as Novel Antagonists of PqsR, an Important Regulator of Pseudomonas aeruginosa Virulence

Michael Zender, Tobias Klein, Claudia Henn, +7

Journal of Medicinal Chemistry

Microbial PathogensMolecular BiologyEscherichia ColiAntimicrobial ChemotherapyBacterial Pathogens +19

Elevated pCO₂ affects the lactate metabolic shift in CHO cell culture processes

Matthias Brunner, Philipp Doppler, Tobias Klein, +2

Engineering in Life Sciences