Tobias Klein

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

Tobias Klein, Daniela Abgottspon, Matthias Wittwer et al. · Journal of Medicinal Chemistry · 2010 · 197 citations · Full text

Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution

Hemanshu Mundhada, Jose Miguel Seoane, Konstantin Schneider et al. · Metabolic Engineering · 2016 · 149 citations

Biology, Biosynthesis, Adaptive Laboratory Evolution +11

Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

Kanchana Rueksomtawin Kildegaard, Niels Bjerg Jensen, Konstantin Schneider et al. · Microbial Cell Factories · 2016 · 125 citations · Full text

Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

Julie A. Tucker, Tobias Klein, J. Breed et al. · Structure · 2014 · 117 citations

Protein Function, Signaling Pathway, Structural Insights +8

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Matthias Negri et al. · Journal of Medicinal Chemistry · 2009 · 75 citations · Full text