Concepedia

Prion Conformational Conversion

Prion Conformational Conversion is a biochemical process in which a normally folded prion protein (PrP^C) undergoes a structural transformation into an aberrantly folded, self-propagating isoform (PrP^Sc) that serves as a template for further pathological misfolding.

454

Publications

40.9K

Citations

1.7K

Authors

586

Institutions

Publications per year

2017–2026

64

Parents

Publications

454

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations

, , +17

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

, , +14

Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant

Tricia R. Serio, Anil G. Cashikar, Anthony S. Kowal et al. · Science · 2000 · 964 citations · Full text

, , +17

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

Glenn C. Telling, Piero Parchi, Stephen J. DeArmond et al. · Science · 1996 · 872 citations

, , +17

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

Stanley B. Prusiner, Michael Scott, Dallas Foster et al. · Cell · 1990 · 869 citations

, , +15

1–5 of 454

Authors

1.7K

  1. SB
    Stanley B. Prusiner

    University of California, San Francisco, United States

    29 publications · 7.7K citations

    26

    h-index

  2. WK
    Witold K. Surewicz

    Case Western Reserve University, United States

    24 publications · 2.8K citations

    24

    h-index

  3. FE
    Fred E. Cohen

    University of California, San Francisco, United States

    15 publications · 6K citations

    15

    h-index

  4. BC
    Byron Caughey

    National Institute of Allergy and Infectious Diseases, United States

    15 publications · 1.8K citations

    14

    h-index

  5. SL
    Susan Lindquist

    Howard Hughes Medical Institute, United States

    14 publications · 3.1K citations

    14

    h-index

1–5 of 1.7K

Institutions

586

  1. University of California, San Francisco

    San Francisco, United States

    35 h-index

    203 publications

    79.9K citations

  2. Case Western Reserve University

    Cleveland, United States

    29 h-index

    141 publications

    13.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    46 publications

    10.4K citations

  4. National Institutes of Health

    Bethesda, United States

    17 h-index

    56 publications

    5.3K citations

  5. Scripps Research Institute

    San Diego, United States

    17 h-index

    71 publications

    17.6K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    66 publications

    2.6K citations

  7. University of Alberta

    Edmonton, Canada

    15 h-index

    46 publications

    2K citations

  8. University of Maryland, Baltimore

    Baltimore, United States

    14 h-index

    51 publications

    4.5K citations

1–8 of 586

Venues

  1. Journal of Biological Chemistry

    JBC · 63 publications · 6.5K citations

    44

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 35 publications · 8.8K citations

    34

    h-index

  3. Biochemistry

    35 publications · 2.6K citations

    26

    h-index

  4. PLoS Pathogens

    22 publications · 1.6K citations

    19

    h-index

  5. Journal of Molecular Biology

    JMB · 17 publications · 1.7K citations

    17

    h-index

1–5