Concepedia

Precision Genomic Engineering

Precision Genomic Engineering is a genome integration strategy that enables targeted, controlled modification of specific genomic loci with high accuracy and minimal off-target effects, distinguished from broader genetic manipulation techniques by its emphasis on spatial, temporal, and functional specificity in genomic alterations.

115

Publications

14.4K

Citations

733

Authors

242

Institutions

Publications per year

2017–2026

50

Parents

Publications

115

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

Prashant Mali, John Aach, P. Benjamin Stranges et al. · Nature Biotechnology · 2013 · 1.8K citations · Full text

, , +14

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon, Shengdar Q. Tsai, Cyd Khayter et al. · Nature Biotechnology · 2012 · 1.2K citations

, , +8

A prudent path forward for genomic engineering and germline gene modification

David Baltimore, Paul Berg, Michael Botchan et al. · Science · 2015 · 705 citations · Full text

, , +15

Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange

Laura R. Hmelo, Bradley R. Borlee, Henrik Almblad et al. · Nature Protocols · 2015 · 609 citations · Full text

, , +7

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

Farren J. Isaacs, Peter A. Carr, Harris H. Wang et al. · Science · 2011 · 573 citations · Full text

, , +14

1–5 of 115

Authors

733

  1. GM
    George M. Church

    Harvard University, United States

    6 publications · 3.4K citations

    6

    h-index

  2. HH
    Harris H. Wang

    Columbia University, United States

    5 publications · 1K citations

    5

    h-index

  3. KJ
    Karl J. Clark

    Mayo Clinic, United States

    3 publications · 154 citations

    3

    h-index

  4. RT
    Ryan T. Gill

    University of Colorado Boulder, United States

    3 publications · 466 citations

    3

    h-index

  5. SC
    Stephen C. Ekker

    Mayo Clinic, United States

    3 publications · 154 citations

    3

    h-index

1–5 of 733

Institutions

242

  1. Harvard University

    Cambridge, United States

    11 h-index

    50 publications

    28.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    27 publications

    4.8K citations

  3. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    20 publications

    3.2K citations

  4. Stanford University

    Stanford, United States

    5 h-index

    23 publications

    5K citations

  5. Peking University

    Beijing, China

    5 h-index

    20 publications

    5.3K citations

  6. Columbia University

    New York, United States

    5 h-index

    13 publications

    686 citations

  7. University of Chinese Academy of Sciences

    Beijing, China

    4 h-index

    17 publications

    922 citations

  8. University of California San Diego

    San Diego, United States

    4 h-index

    24 publications

    1.1K citations

1–8 of 242

Venues

  1. Nucleic Acids Research

    15 publications · 938 citations

    15

    h-index

  2. Nature Communications

    7 publications · 331 citations

    7

    h-index

  3. PLoS ONE

    5 publications · 712 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 1.2K citations

    5

    h-index

  5. Nature Biotechnology

    4 publications · 3.5K citations

    4

    h-index

1–5