Concepedia

Precise Genome Insertion

Precise Genome Insertion is a genome engineering technique that enables the targeted integration of exogenous genetic material into a specific genomic locus with high accuracy and minimal off-target effects, distinguishing it from random or imprecise insertion methods by its reliance on sequence-specific nucleases and homology-directed repair mechanisms.

35

Publications

2.3K

Citations

223

Authors

103

Institutions

Publications per year

2017–2026

15

Variants

Precision Genome Insertion

Parents

Publications

35

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Matthew T. N. Yarnall, Eleonora Ioannidi, Cian Schmitt-Ulms et al. · Nature Biotechnology · 2022 · 429 citations · Full text

, , +15

Phage-assisted evolution and protein engineering yield compact, efficient prime editors

Jordan L. Doman, Smriti Pandey, Monica E. Neugebauer et al. · Cell · 2023 · 285 citations · Full text

, , +17

Precise insertion and guided editing of higher plant genomes using Cpf1 CRISPR nucleases

Matthew B. Begemann, Benjamin N. Gray, Emma January et al. · Scientific Reports · 2017 · 184 citations · Full text

, , +16

Splinkerette PCR for Mapping Transposable Elements in Drosophila

Christopher J. Potter, Liqun Luo · PLoS ONE · 2010 · 158 citations · Full text

, , +17

Homologous recombination: a basis for targeted genome optimization in crop species such as maize

Kathleen D’Halluin, Chantal Vanderstraeten, Ellen Stals et al. · Plant Biotechnology Journal · 2007 · 98 citations · Full text

, , +17

1–5 of 35

Authors

223

  1. EI
    Eleonora Ioannidi

    ETH Zurich, Switzerland

    2 publications · 462 citations

    2

    h-index

  2. JS
    Jonathan S. Gootenberg

    McGovern Institute for Brain Research, United States

    2 publications · 462 citations

    2

    h-index

  3. CA
    Christopher A. Vakulskas

    Integrated DNA Technologies (United States), United States

    2 publications · 462 citations

    2

    h-index

  4. MT
    Matthew T. N. Yarnall

    McGovern Institute for Brain Research, United States

    2 publications · 462 citations

    2

    h-index

  5. KH
    Kevin Holden

    Synthego (United States), United States

    2 publications · 462 citations

    2

    h-index

1–5 of 223

Institutions

103

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    19 publications

    4.4K citations

  2. Synthego (United States)

    Menlo Park, United States

    2 h-index

    8 publications

    1.8K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    20 publications

    4.6K citations

  4. University of California, Berkeley

    Berkeley, United States

    2 h-index

    9 publications

    553 citations

  5. Integrated DNA Technologies (United States)

    Coralville, United States

    2 h-index

    6 publications

    1.4K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    3 publications

    36 citations

  7. ETH Zurich

    Zurich, Switzerland

    2 h-index

    2 publications

    462 citations

  8. University of Toronto

    Toronto, Canada

    2 h-index

    4 publications

    128 citations

1–8 of 103

Venues

  1. Scientific Reports

    3 publications · 241 citations

    3

    h-index

  2. Genetics

    3 publications · 122 citations

    3

    h-index

  3. PLoS ONE

    2 publications · 195 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 90 citations

    2

    h-index

  5. Nature Communications

    2 publications · 96 citations

    2

    h-index

1–5