Kevin Holden

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou et al. · Science · 2020 · 794 citations · Full text

Viral Diagnostics, Covid-19 Pandemic, Viral Pathogenesis +12

Inference of CRISPR Edits from Sanger Trace Data

David S. Conant, Tim Hsiau, Nicholas A. Rossi et al. · The CRISPR Journal · 2022 · 785 citations

Engineering, Genetics, Genomics +17

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

Ruofan Wang, Camille R. Simoneau, Jessie Kulsuptrakul et al. · Cell · 2020 · 443 citations · Full text

Viral Evolution, Viral Diagnostics, Common Cold Coronaviruses +5

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Matthew T. N. Yarnall, Eleonora Ioannidi, Cian Schmitt-Ulms et al. · Nature Biotechnology · 2022 · 395 citations · Full text

Drag-and-drop Genome Insertion, Genetics, Genetic Engineering +11

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Tanja Rothgangl, Melissa K. Dennis, Paulo J.C. Lin et al. · Nature Biotechnology · 2021 · 352 citations · Full text