Concepedia

Potency Landscape Analysis

Potency Landscape Analysis is a computational framework in medicinal chemistry that characterizes the discontinuous relationship between small changes in molecular structure and large shifts in biological activity by mapping activity cliff formations across chemical space.

14

Publications

863

Citations

25

Authors

7

Institutions

Publications per year

2017–2026

1

Parents

Publications

14

Assessing the impact of generative AI on medicinal chemistry

W. Patrick Walters, Mark A. Murcko · Nature Biotechnology · 2020 · 253 citations

, , +14

Recent Progress in Understanding Activity Cliffs and Their Utility in Medicinal Chemistry

Dagmar Stumpfe, Ye Hu, Dilyana Dimova et al. · Journal of Medicinal Chemistry · 2013 · 212 citations

, , +16

Rationalizing Three-Dimensional Activity Landscapes and the Influence of Molecular Representations on Landscape Topology and the Formation of Activity Cliffs

Lisa Peltason, Preeti Iyer, Jürgen Bajorath · Journal of Chemical Information and Modeling · 2010 · 84 citations

, , +12

Extending the Activity Cliff Concept: Structural Categorization of Activity Cliffs and Systematic Identification of Different Types of Cliffs in the ChEMBL Database

Ye Hu, Jürgen Bajorath · Journal of Chemical Information and Modeling · 2012 · 69 citations

, , +14

Design of Multitarget Activity Landscapes That Capture Hierarchical Activity Cliff Distributions

Dilyana Dimova, Mathias J. Wawer, Anne Mai Wassermann et al. · Journal of Chemical Information and Modeling · 2011 · 49 citations

, , +17

1–5 of 14

Authors

25

  1. JB
    Jürgen Bajorath

    University of Bonn, Germany

    10 publications · 530 citations

    10

    h-index

  2. PI
    Preeti Iyer

    University of Bonn, Germany

    5 publications · 141 citations

    5

    h-index

  3. VN
    Vigneshwaran Namasivayam

    University of Bonn, Germany

    3 publications · 52 citations

    3

    h-index

  4. YH
    Ye Hu

    University of Bonn, Germany

    3 publications · 301 citations

    3

    h-index

  5. AA
    Alexander Alanine

    Roche (Switzerland), Switzerland

    2 publications · 48 citations

    2

    h-index

1–5 of 25

Institutions

7

  1. University of Bonn

    Bonn, Germany

    10 h-index

    29 publications

    1.7K citations

  2. Roche (Switzerland)

    Basel, Switzerland

    2 h-index

    8 publications

    192 citations

  3. ETH Zurich

    Zurich, Switzerland

    2 h-index

    10 publications

    240 citations

  4. Relay Therapeutics (United States)

    Cambridge, United States

    1 h-index

    2 publications

    506 citations

  5. Translational Genomics Research Institute

    Phoenix, United States

    1 h-index

    1 publications

    10 citations

  6. University of Arizona

    Tucson, United States

    1 h-index

    1 publications

    10 citations

  7. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    1 h-index

    2 publications

    64 citations

1–7 of 7

Venues

  1. Journal of Chemical Information and Modeling

    JCIM · 7 publications · 274 citations

    7

    h-index

  2. Nature Biotechnology

    1 publications · 253 citations

    1

    h-index

  3. Bioorganic & Medicinal Chemistry

    1 publications · 32 citations

    1

    h-index

  4. PLoS ONE

    1 publications · 34 citations

    1

    h-index

  5. Angewandte Chemie

    1 publications · 10 citations

    1

    h-index

1–5