Concepedia

Positional Scanning Libraries

Positional Scanning Libraries is a combinatorial library design strategy in peptide chemistry that systematically varies amino acids at specific positions across multiple sublibraries to enable the identification of optimal residues for ligand binding through positional functional screening.

110

Publications

7.8K

Citations

511

Authors

188

Institutions

Publications per year

2017–2026

15

Parents

Publications

110

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Wioletta Rut, Zongyang Lv, Mikołaj Żmudziński et al. · Science Advances · 2020 · 483 citations · Full text

, , +14

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

Toshihiko Takeuchi, Jennifer L. Harris, Wei Huang et al. · Journal of Biological Chemistry · 2000 · 437 citations · Full text

, , +17

Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

Youngchool Choe, Francesco Leonetti, Doron C. Greenbaum et al. · Journal of Biological Chemistry · 2006 · 422 citations · Full text

, , +17

Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries

John Sidney, Erika Assarsson, Carrie Moore et al. · Immunome Research · 2008 · 343 citations · Full text

, , +17

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

Clemencia Pinilla, Jens Appel, Philippe Blanc et al. · PubMed · 1992 · 329 citations

, , +17

1–5 of 110

Authors

511

  1. RA
    Richard A. Houghten

    Torrey Pines Institute For Molecular Studies, United States

    27 publications · 1.4K citations

    21

    h-index

  2. CP
    Clemencia Pinilla

    Torrey Pines Institute For Molecular Studies, United States

    19 publications · 1.5K citations

    15

    h-index

  3. JR
    Jon R. Appel

    Torrey Pines Institute For Molecular Studies, United States

    11 publications · 577 citations

    11

    h-index

  4. CS
    Charles S. Craik

    University of California, San Francisco, United States

    10 publications · 1.7K citations

    10

    h-index

  5. MA
    Marc A. Giulianotti

    Torrey Pines Institute For Molecular Studies, United States

    9 publications · 294 citations

    9

    h-index

1–5 of 511

Institutions

188

  1. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    24 h-index

    128 publications

    6.9K citations

  2. University of California, San Francisco

    San Francisco, United States

    11 h-index

    28 publications

    6.1K citations

  3. Scripps Research Institute

    San Diego, United States

    7 h-index

    19 publications

    1.2K citations

  4. General Atomics (United States)

    San Diego, United States

    6 h-index

    16 publications

    752 citations

  5. University of Copenhagen

    Copenhagen, Denmark

    4 h-index

    11 publications

    858 citations

  6. Universitat de València

    Valencia, Spain

    4 h-index

    24 publications

    1K citations

  7. University of South Florida

    Tampa, United States

    3 h-index

    8 publications

    376 citations

  8. Wrocław University of Science and Technology

    Wroclaw, Poland

    3 h-index

    10 publications

    2K citations

1–8 of 188

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 327 citations

    10

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 1.5K citations

    7

    h-index

  3. PubMed

    Repository · 7 publications · 501 citations

    7

    h-index

  4. The Journal of Immunology

    JI · 7 publications · 745 citations

    7

    h-index

  5. Humana Press eBooks

    Ebook platform · 3 publications · 50 citations

    3

    h-index

1–5