Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Puwei Yuan, Mark Bartlam, Zhiyong Lou, +10

Nature

Virus StructureCrystal StructureViral Polymerase StructureProtein AssemblyBiochemistry +8

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Wioletta Rut, Zongyang Lv, Mikołaj Żmudziński, +8

Science Advances

Protein AssemblyBiomolecular Structure PredictionMolecular BiologyViral Structural ProteinProtein Folding +16

Structural insights into protein arginine symmetric dimethylation by PRMT5

Litao Sun, Mingzhu Wang, Zongyang Lv, +5

Proceedings of the National Academy of Sciences

Biomolecular Structure PredictionEpigenetic ChangeActive SitesMolecular BiologySymmetric Dimethylation +15

Crystal structure of a human ubiquitin E1–ubiquitin complex reveals conserved functional elements essential for activity

Zongyang Lv, Katelyn Williams, Lingmin Yuan, +2

Journal of Biological Chemistry

Huba1 MechanismCrystal StructureProtein FunctionInteractomicsMedicine +12

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Zongyang Lv, Lingmin Yuan, James H. Atkison, +7

Nature Communications

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

Lingmin Yuan, Zongyang Lv, James H. Atkison, +1

Nature Communications

S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity

Zongyang Lv, Kimberly A. Rickman, Lingmin Yuan, +7

Molecular Cell

Protein FunctionMolecular BiologyHeme SignalingNovel Regulatory MechanismMedicine +4

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Stephanie Patchett, Zongyang Lv, Wioletta Rut, +4

Cell Reports

Protein AssemblyImmunologyMolecular BiologyViral Structural ProteinSars-cov-2 Papain-like Protease +16

Protomer Roles in Chloroplast Chaperonin Assembly and Function

Cuicui Bai, Peng Guo, Qian Zhao, +9

Molecular Plant

BiologyPlant Molecular BiologyNatural SciencesProtomer RolesMolecular Biology +2

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Mikołaj Żmudziński, Wioletta Rut, Kamila Olech, +16

Scientific Reports