Concepedia

Pka Modulation

pKa Modulation is a chemical strategy within electronic effects in bioisosterism that refers to the deliberate alteration of the acid dissociation constant (pKa) of a functional group through electronic modifications, thereby influencing its ionization state and molecular properties while preserving biological activity.

256

Publications

15.6K

Citations

1.3K

Authors

443

Institutions

Publications per year

2017–2026

36

Parents

Publications

256

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

Rajesh Narasimamurthy, Megumi Hatori, Surendra Kumar Nayak et al. · Proceedings of the National Academy of Sciences · 2012 · 415 citations · Full text

, , +17

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

Torkel Vang, Knut Martin Torgersen, Vibeke Sundvold et al. · The Journal of Experimental Medicine · 2001 · 329 citations · Full text

, , +17

Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways

Marilene H. Lopes, Glaucia N. M. Hajj, Angelita Muras et al. · Journal of Neuroscience · 2005 · 280 citations · Full text

, , +17

Tamoxifen resistance by a conformational arrest of the estrogen receptor α after PKA activation in breast cancer

Rob Michalides, Alexander Griekspoor, Astrid Balkenende et al. · Cancer Cell · 2004 · 259 citations · Full text

, , +17

Protein Kinase A Phosphorylation of the Ryanodine Receptor Does Not Affect Calcium Sparks in Mouse Ventricular Myocytes

Yanxia Li, Evangelia G. Kranias, Gregory A. Mignery et al. · Circulation Research · 2002 · 259 citations · Full text

, , +17

1–5 of 256

Authors

1.3K

  1. DM
    Donald M. Bers

    University of California, Davis, United States

    7 publications · 782 citations

    7

    h-index

  2. KT
    Kjetil Taskén

    University of Oslo, Norway

    5 publications · 519 citations

    5

    h-index

  3. TS
    Todd Scheuer

    University of Washington, United States

    4 publications · 450 citations

    4

    h-index

  4. GS
    G. Stanley McKnight

    University of Washington, United States

    3 publications · 359 citations

    3

    h-index

  5. WA
    William A. Catterall

    University of Washington, United States

    3 publications · 292 citations

    3

    h-index

1–5 of 1.3K

Institutions

443

  1. University of Washington

    Seattle, United States

    9 h-index

    38 publications

    3.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    28 publications

    1.2K citations

  3. Inserm

    Paris, France

    8 h-index

    57 publications

    2.1K citations

  4. The University of Osaka

    Osaka, Japan

    6 h-index

    22 publications

    593 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    13 publications

    901 citations

  6. McGill University

    Montreal, Canada

    5 h-index

    22 publications

    2.2K citations

  7. University of California, Davis

    Davis, United States

    5 h-index

    18 publications

    935 citations

  8. Johns Hopkins University

    Baltimore, United States

    5 h-index

    14 publications

    997 citations

1–8 of 443

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1.3K citations

    16

    h-index

  2. Journal of Neuroscience

    15 publications · 1.4K citations

    14

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 1.3K citations

    10

    h-index

  4. PLoS ONE

    7 publications · 282 citations

    7

    h-index

  5. The Journal of Physiology

    7 publications · 494 citations

    7

    h-index

1–5