Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

Torkel Vang, Mauro Congia, Maria Doloretta Macis, +9

Nature Genetics

Autoimmune DiseaseGain-of-function VariantAutoantibody ProductionImmunologyAutoimmunity +4

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

Torkel Vang, Knut Martin Torgersen, Vibeke Sundvold, +6

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationCell DeathImmunologic Mechanism +17

Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts

Knut Martin Torgersen, Torkel Vang, Hilde Abrahamsen, +6

Journal of Biological Chemistry

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismImmunotherapy +17

TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling

Hilde Abrahamsen, George S. Baillie, Jacob Ngai, +7

The Journal of Immunology

LYP inhibits T-cell activation when dissociated from CSK

Torkel Vang, Wallace H. Liu, Laurence Delacroix, +15

Nature Chemical Biology

Signal TransductionReceptor Tyrosine KinaseImmunologyT-cell ActivationMedicine +3

Inhibition of Antigen-Specific T Cell Proliferation and Cytokine Production by Protein Kinase A Type I

Einar Martin Aandahl, Walter J. Moretto, Patrick Haslett, +4

The Journal of Immunology

Combined Spatial and Enzymatic Regulation of Csk by cAMP and Protein Kinase A Inhibits T Cell Receptor Signaling

Torkel Vang, Hilde Abrahamsen, Sondre Myklebust, +2

Journal of Biological Chemistry

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells

Maria Elisabeth Kalland, Nikolaus G. Oberprieler, Torkel Vang, +2

The Journal of Immunology

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationCell Death +21

Multidentate Small-Molecule Inhibitors of <i>Vaccinia</i> H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells

Shuangding Wu, Sofie Vossius, Souad Rahmouni, +12

Journal of Medicinal Chemistry

Multidentate Small-molecule InhibitorsImmunologyPhosphatase Decrease ProliferationImmunotherapeuticsCancer Biology +18

Protein Kinase A Intersects Src Signaling in Membrane Microdomains

Hilde Abrahamsen, Torkel Vang, Kjetil Taskén

Journal of Biological Chemistry