Concepedia

Peptide Scaffold Engineering

Peptide Scaffold Engineering is a methodological framework in peptide drug discovery that involves the rational design and structural optimization of peptide backbones to enhance stability, bioavailability, and target specificity while preserving functional conformation.

284

Publications

14.2K

Citations

1.4K

Authors

429

Institutions

Publications per year

2017–2026

75

Parents

Publications

284

Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

Stephen Hanessian, Grant McNaughton‐Smith, Henry‐Georges Lombart et al. · Tetrahedron · 1997 · 630 citations

, , +16

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R. White, Chad M. Renzelman, Arthur C Rand et al. · Nature Chemical Biology · 2011 · 384 citations

, , +10

Slow release of molecules in self-assembling peptide nanofiber scaffold

Yusuke Nagai, Larry D. Unsworth, Sotirios Koutsopoulos et al. · Journal of Controlled Release · 2006 · 311 citations

, , +14

Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces

Peter Timmerman, Joris Beld, Wouter C. Puijk et al. · ChemBioChem · 2005 · 294 citations

, , +15

Design and Application of an α‐Helix‐Mimetic Scaffold Based on an Oligoamide‐Foldamer Strategy: Antagonism of the Bak BH3/Bcl‐xL Complex

Justin T. Ernst, Jorge Becerril, Hyung Soon Park et al. · Angewandte Chemie International Edition · 2003 · 264 citations · Full text

, , +15

1–5 of 284

Authors

1.4K

  1. DJ
    David J. Craik

    The University of Queensland, Australia

    7 publications · 540 citations

    9

    h-index

  2. SZ
    Shuguang Zhang

    Massachusetts Institute of Technology, United States

    8 publications · 1.1K citations

    8

    h-index

  3. CW
    Chuanliu Wu

    Xiamen University, China

    6 publications · 157 citations

    7

    h-index

  4. AB
    Amos B. Smith

    University of Pennsylvania, United States

    5 publications · 201 citations

    5

    h-index

  5. NL
    Norelle L. Daly

    The University of Queensland, Australia

    5 publications · 539 citations

    5

    h-index

1–5 of 1.4K

Institutions

429

  1. The University of Queensland

    Brisbane, Australia

    13 h-index

    38 publications

    2.3K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    11 h-index

    28 publications

    4.6K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    71 publications

    2.5K citations

  4. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    43 publications

    1.8K citations

  5. Australian Research Council

    Canberra, Australia

    7 h-index

    15 publications

    625 citations

  6. Xiamen University

    Xiamen, China

    7 h-index

    29 publications

    740 citations

  7. Université de Montréal

    Montreal, Canada

    6 h-index

    21 publications

    3.1K citations

  8. Uppsala University

    Uppsala, Sweden

    6 h-index

    28 publications

    842 citations

1–8 of 429

Venues

  1. Organic Letters

    OL · 23 publications · 915 citations

    18

    h-index

  2. Journal of the American Chemical Society

    JACS · 14 publications · 828 citations

    14

    h-index

  3. Bioorganic & Medicinal Chemistry

    13 publications · 368 citations

    12

    h-index

  4. Chemical Communications

    ChemComm · 11 publications · 316 citations

    11

    h-index

  5. Chemistry - A European Journal

    12 publications · 379 citations

    11

    h-index

1–5