Concepedia

Peptide Lead Optimization

Peptide Lead Optimization is a drug discovery process that involves the systematic modification and refinement of initial peptide hits to enhance their pharmacological properties, such as potency, selectivity, metabolic stability, and bioavailability, while maintaining target specificity, within the context of developing viable therapeutic candidates.

47

Publications

2.8K

Citations

365

Authors

98

Institutions

Publications per year

2017–2026

13

Parents

Publications

47

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang, Bradford Graves, Vincent Guerlavais et al. · Proceedings of the National Academy of Sciences · 2013 · 661 citations · Full text

, , +15

Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide

Jan Münch, Ludger Ständker, Knut Adermann et al. · Cell · 2007 · 268 citations · Full text

, , +14

Design of Peptide Inhibitors for the Importin α/β Nuclear Import Pathway by Activity-Based Profiling

Shunichi Kosugi, Masako Hasebe, Tetsuyuki Entani et al. · Chemistry & Biology · 2008 · 251 citations

, , +16

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors

Thomas J. Tucker, Mark W. Embrey, Candice Alleyne et al. · Journal of Medicinal Chemistry · 2021 · 152 citations · Full text

, , +17

Minimum analogue peptide sets (MAPS) for quantitative structure‐activity relationships

Sven Hellberg, Lennart Eriksson, Jörgen Jönsson et al. · International journal of peptide & protein research · 1991 · 140 citations

, , +17

1–5 of 47

Authors

365

  1. VV
    Valeriy V. Pak

    Yunusov Institute of the Chemistry of Plant Substances, Uzbekistan

    3 publications · 82 citations

    3

    h-index

  2. LM
    L. M. Yun

    Korea Food Research Institute, South Korea

    3 publications · 82 citations

    3

    h-index

  3. DY
    Dae Young Kwon

    Korea Food Research Institute, South Korea

    3 publications · 82 citations

    3

    h-index

  4. MK
    Minseon Koo

    Korea Food Research Institute, South Korea

    3 publications · 82 citations

    3

    h-index

  5. RG
    Remo Guerrini

    University of Ferrara, Italy

    2 publications · 33 citations

    2

    h-index

1–5 of 365

Institutions

98

  1. Korea Food Research Institute

    Wanju, South Korea

    3 h-index

    8 publications

    196 citations

  2. Yunusov Institute of the Chemistry of Plant Substances

    Tashkent, Uzbekistan

    3 h-index

    6 publications

    162 citations

  3. University of Ferrara

    Ferrara, Italy

    2 h-index

    5 publications

    89 citations

  4. University of Arizona

    Tucson, United States

    2 h-index

    19 publications

    1.1K citations

  5. Seikei University

    Musashino, Japan

    2 h-index

    3 publications

    40 citations

  6. Vanderbilt University Medical Center

    Nashville, United States

    2 h-index

    13 publications

    787 citations

  7. University of Modena and Reggio Emilia

    Modena, Italy

    2 h-index

    22 publications

    376 citations

  8. Tokyo Medical and Dental University

    Tokyo, Japan

    2 h-index

    5 publications

    60 citations

1–8 of 98

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 377 citations

    8

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    6 publications · 195 citations

    6

    h-index

  3. Bioorganic & Medicinal Chemistry

    3 publications · 47 citations

    3

    h-index

  4. Amino Acids

    2 publications · 68 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 124 citations

    2

    h-index

1–5