Concepedia

Niraparib Therapy

Niraparib Therapy is a targeted pharmacotherapeutic intervention belonging to the class of poly(ADP-ribose) polymerase (PARP) inhibitor treatments, distinguished by its selective inhibition of PARP enzymes to induce synthetic lethality in ovarian cancer cells with homologous recombination repair deficiencies.

192

Publications

16.7K

Citations

1.9K

Authors

724

Institutions

Publications per year

2017–2026

176

Parents

Publications

192

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

Mansoor R. Mirza, Bradley J. Monk, Jørn Herrstedt et al. · New England Journal of Medicine · 2016 · 2.5K citations · Full text

, , +15

Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

Antonio González-Martı́n, Bhavana Pothuri, Ignace Vergote et al. · New England Journal of Medicine · 2019 · 2.3K citations · Full text

, , +15

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai, Shar-yin N. Huang, Amèlie Renaud et al. · Molecular Cancer Therapeutics · 2013 · 758 citations · Full text

, , +15

Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma

Panagiotis A. Konstantinopoulos, Steven Waggoner, Gregory A. Vidal et al. · JAMA Oncology · 2019 · 560 citations · Full text

, , +17

The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

Shahneen Sandhu, William R. Schelman, George Wilding et al. · The Lancet Oncology · 2013 · 558 citations

, , +12

1–5 of 192

Authors

1.9K

  1. MR
    Mansoor Raza Mirza

    Rigshospitalet, Denmark

    25 publications · 1.4K citations

    18

    h-index

  2. BJ
    Bradley J. Monk

    Creighton University, United States

    22 publications · 6K citations

    15

    h-index

  3. UA
    Ursula A. Matulonis

    Dana-Farber Cancer Institute, United States

    20 publications · 4.6K citations

    15

    h-index

  4. AG
    Antonio González-Martı́n

    Clinica Universidad de Navarra, Spain

    17 publications · 5.3K citations

    14

    h-index

  5. AR
    Andrés Redondo

    Hospital Universitario La Paz, Spain

    18 publications · 5.5K citations

    13

    h-index

1–5 of 1.9K

Institutions

724

  1. Tesaro (United States)

    Waltham, United States

    24 h-index

    121 publications

    25.7K citations

  2. Rigshospitalet

    Copenhagen, Denmark

    19 h-index

    60 publications

    9.6K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    18 h-index

    54 publications

    6.3K citations

  4. Copenhagen University Hospital

    Copenhagen, Denmark

    18 h-index

    59 publications

    9.5K citations

  5. Spanish Ovarian Cancer Research Group

    Barcelona, Spain

    17 h-index

    82 publications

    67.8K citations

  6. The University of Texas MD Anderson Cancer Center

    Houston, United States

    16 h-index

    65 publications

    8K citations

  7. GlaxoSmithKline (United States)

    Philadelphia, United States

    15 h-index

    64 publications

    11.1K citations

  8. Harvard University

    Cambridge, United States

    15 h-index

    25 publications

    3.9K citations

1–8 of 724

Venues

  1. Journal of Clinical Oncology

    28 publications · 1.3K citations

    17

    h-index

  2. Gynecologic Oncology

    15 publications · 588 citations

    14

    h-index

  3. Annals of Oncology

    12 publications · 918 citations

    10

    h-index

  4. The Lancet Oncology

    6 publications · 1.8K citations

    6

    h-index

  5. International Journal of Gynecological Cancer

    6 publications · 146 citations

    6

    h-index

1–5