Concepedia

Modular Polyketide Biosynthesis

Modular Polyketide Biosynthesis is a biosynthetic mechanism in which polyketide natural products are assembled in an assembly-line fashion by multimodular enzyme complexes, with each module catalyzing a defined set of reactions to incorporate and modify a single extender unit, thereby enabling programmed, stepwise chain elongation and functionalization.

285

Publications

22.5K

Citations

951

Authors

266

Institutions

Publications per year

2017–2026

61

Parents

Publications

285

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science · 1991 · 909 citations

, , +17

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of <i>E. coli</i>

Blaine A. Pfeifer, Suzanne J. Admiraal, Hugo Gramajo et al. · Science · 2001 · 760 citations

, , +17

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson et al. · Proceedings of the National Academy of Sciences · 1999 · 461 citations

, , +17

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

Torsten Schwecke, Jesús F. Aparicio, István Molnár et al. · Proceedings of the National Academy of Sciences · 1995 · 448 citations

, , +16

Structural and Functional Characterization of Three Polyketide Synthase Gene Clusters in <i>Bacillus amyloliquefaciens</i> FZB 42

Xiaohua Chen, Joachim Vater, Jörn Piel et al. · Journal of Bacteriology · 2006 · 382 citations · Full text

, , +13

1–5 of 285

Authors

951

  1. CK
    Chaitan Khosla

    Stanford University, United States

    50 publications · 4.8K citations

    38

    h-index

  2. DE
    David E. Cane

    Brown University, United States

    36 publications · 3.8K citations

    32

    h-index

  3. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    40 publications · 3.5K citations

    32

    h-index

  4. DH
    David H. Sherman

    University of Michigan, United States

    23 publications · 2.1K citations

    21

    h-index

  5. JS
    James Staunton

    University of Cambridge, United Kingdom

    21 publications · 2.3K citations

    20

    h-index

1–5 of 951

Institutions

266

  1. Stanford University

    Stanford, United States

    36 h-index

    186 publications

    15.4K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    36 h-index

    234 publications

    26.2K citations

  3. Brown University

    Providence, United States

    29 h-index

    122 publications

    10.7K citations

  4. University of Michigan

    Ann Arbor, United States

    19 h-index

    99 publications

    12.8K citations

  5. The University of Texas at Austin

    Austin, United States

    18 h-index

    85 publications

    4.2K citations

  6. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    13 h-index

    52 publications

    2.2K citations

  7. University of California, Berkeley

    Berkeley, United States

    12 h-index

    47 publications

    1.6K citations

  8. Friedrich Schiller University Jena

    Jena, Germany

    10 h-index

    10 publications

    426 citations

1–8 of 266

Venues

  1. Journal of the American Chemical Society

    JACS · 37 publications · 2.4K citations

    32

    h-index

  2. Chemistry & Biology

    21 publications · 1.8K citations

    21

    h-index

  3. Biochemistry

    20 publications · 963 citations

    18

    h-index

  4. ChemBioChem

    21 publications · 1K citations

    17

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 3K citations

    15

    h-index

1–5