Concepedia

Mixture-based Library Synthesis

Mixture-Based Library Synthesis is a combinatorial chemistry strategy that involves the concurrent synthesis of large collections of chemical compounds through the stepwise coupling of building blocks in a split-and-pool manner, where each synthetic step generates a mixture of intermediates carried forward as pooled entities, thereby enabling the rapid generation of molecular diversity through recombination of building blocks across multiple reaction cycles.

23

Publications

1.1K

Citations

80

Authors

21

Institutions

Publications per year

2017–2026

2

Parents

Publications

23

Solution-Phase Preparation of a 560-Compound Library of Individual Pure Mappicine Analogues by Fluorous Mixture Synthesis

Wei Zhang, Zhiyong Luo, Christine Hiu‐Tung Chen et al. · Journal of the American Chemical Society · 2002 · 132 citations

, , +17

OptCAMD: An optimization-based framework and tool for molecular and mixture product design

Qilei Liu, Lei Zhang, Linlin Liu et al. · Computers & Chemical Engineering · 2019 · 116 citations

, , +13

Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries

Clemencia Pinilla, Jon R. Appel, Eva Borràs et al. · Nature Medicine · 2003 · 101 citations

, , +13

Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A

Peter Wipf, Jonathan T. Reeves, Raghavan Balachandran et al. · Journal of the American Chemical Society · 2000 · 94 citations

, , +17

Liquid-Phase Combinatorial Synthesis of Alicyclic<i>β</i>-Lactams via Ugi Four-Component Reaction

Szilvia Gedey, Johan Van der Eycken, Ferenc Fülöp · Organic Letters · 2002 · 86 citations

, , +16

1–5 of 23

Authors

80

  1. RA
    Richard A. Houghten

    Torrey Pines Institute For Molecular Studies, United States

    8 publications · 275 citations

    8

    h-index

  2. AN
    Adel Nefzi

    Torrey Pines Institute For Molecular Studies, United States

    5 publications · 192 citations

    6

    h-index

  3. JM
    John M. Ostresh

    Torrey Pines Institute For Molecular Studies, United States

    3 publications · 43 citations

    3

    h-index

  4. KJ
    Kate J. Reilley

    Torrey Pines Institute For Molecular Studies, United States

    2 publications · 72 citations

    2

    h-index

  5. JR
    Jon R. Appel

    Torrey Pines Institute For Molecular Studies, United States

    2 publications · 118 citations

    2

    h-index

1–5 of 80

Institutions

21

  1. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    10 h-index

    39 publications

    1.3K citations

  2. General Atomics (United States)

    San Diego, United States

    6 h-index

    18 publications

    369 citations

  3. University of Pittsburgh

    Pittsburgh, United States

    3 h-index

    11 publications

    849 citations

  4. University of Szeged

    Szeged, Hungary

    2 h-index

    6 publications

    294 citations

  5. Fluorous Technologies (United States)

    Pittsburgh, United States

    2 h-index

    9 publications

    813 citations

  6. University at Buffalo, State University of New York

    Buffalo, United States

    1 h-index

    3 publications

    90 citations

  7. Institut de Chimie Moléculaire et des Matériaux d'Orsay

    Orsay, France

    1 h-index

    5 publications

    120 citations

  8. Ghent University

    Ghent, Belgium

    1 h-index

    3 publications

    258 citations

1–8 of 21

Venues

  1. Journal of Combinatorial Chemistry

    4 publications · 133 citations

    4

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    4 publications · 134 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 226 citations

    2

    h-index

  4. Biopolymers

    2 publications · 29 citations

    2

    h-index

  5. Organic Letters

    OL · 1 publications · 86 citations

    1

    h-index

1–5