Concepedia

Mitochondrial Mutation Accumulation

Mitochondrial Mutation Accumulation is a biological phenomenon characterized by the progressive retention and increase of deleterious genetic alterations in mitochondrial DNA over time, distinguished from nuclear mutation accumulation by its maternal inheritance pattern, high mutation rate, and limited repair mechanisms in the mitochondrial genome.

226

Publications

19.5K

Citations

1.1K

Authors

392

Institutions

Publications per year

2017–2026

41

Parents

Publications

226

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

Gino Cortopassi, Darryl Shibata, Nay-Wei Soong et al. · Proceedings of the National Academy of Sciences · 1992 · 640 citations · Full text

, , +14

Mitochondrial DNA mutations in human colonic crypt stem cells

Robert W. Taylor, Martin Barron, Gillian M. Borthwick et al. · Journal of Clinical Investigation · 2003 · 520 citations · Full text

, , +17

Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

Entela Bua, Jody Johnson, Allen Herbst et al. · The American Journal of Human Genetics · 2006 · 433 citations · Full text

, , +14

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Scott R. Kennedy, Jesse J. Salk, Michael Schmitt et al. · PLoS Genetics · 2013 · 377 citations · Full text

, , +13

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

M.‐T. Lin · Human Molecular Genetics · 2002 · 365 citations

, , +16

1–5 of 226

Authors

1.1K

  1. DM
    Douglass M. Turnbull

    Newcastle University, United Kingdom

    10 publications · 1.2K citations

    10

    h-index

  2. YW
    Yau‐Huei Wei

    National Yang Ming Chiao Tung University, Taiwan

    9 publications · 1K citations

    9

    h-index

  3. DK
    Damian K. Dowling

    Monash University, Australia

    8 publications · 671 citations

    8

    h-index

  4. SR
    Scott R. Kennedy

    University of Washington, United States

    7 publications · 863 citations

    7

    h-index

  5. ML
    Michael Lynch

    Indiana University Bloomington, United States

    7 publications · 1.7K citations

    7

    h-index

1–5 of 1.1K

Institutions

392

  1. Newcastle University

    Newcastle upon Tyne, United Kingdom

    17 h-index

    75 publications

    7.4K citations

  2. Monash University

    Melbourne, Australia

    14 h-index

    39 publications

    3.4K citations

  3. University of Washington

    Seattle, United States

    12 h-index

    60 publications

    5.4K citations

  4. University College London

    London, United Kingdom

    9 h-index

    17 publications

    762 citations

  5. Wellcome Centre for Mitochondrial Research

    Newcastle upon Tyne, United Kingdom

    8 h-index

    36 publications

    2.4K citations

  6. National Yang Ming Chiao Tung University

    Hsinchu, Taiwan

    7 h-index

    24 publications

    2K citations

  7. Newcastle Hospitals - Campus for Ageing and Vitality

    Newcastle upon Tyne, United Kingdom

    7 h-index

    18 publications

    921 citations

  8. University of Wisconsin–Madison

    Madison, United States

    6 h-index

    18 publications

    4.5K citations

1–8 of 392

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 2.1K citations

    12

    h-index

  2. PubMed

    Repository · 10 publications · 979 citations

    10

    h-index

  3. Molecular Biology and Evolution

    MBE · 9 publications · 1.1K citations

    9

    h-index

  4. PLoS ONE

    8 publications · 389 citations

    8

    h-index

  5. Aging Cell

    7 publications · 408 citations

    7

    h-index

1–5