Concepedia

Metabolite Trapping

Metabolite Trapping is a biochemical method used in drug metabolism studies that involves the covalent capture of reactive metabolites by nucleophilic trapping agents to facilitate their detection and characterization.

47

Publications

1.5K

Citations

200

Authors

68

Institutions

Publications per year

2017–2026

5

Parents

Publications

47

Dansyl Glutathione as a Trapping Agent for the Quantitative Estimation and Identification of Reactive Metabolites

Jinping Gan, Timothy W. Harper, Mei-Mann Hsueh et al. · Chemical Research in Toxicology · 2005 · 177 citations

, , +16

Stable-Isotope Trapping and High-Throughput Screenings of Reactive Metabolites Using the Isotope MS Signature

Zhengyin Yan, Gary W. Caldwell · Analytical Chemistry · 2004 · 127 citations

, , +17

A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammonium Glutathione Analogues

John R. Soglia, Leonard G. Contillo, Amit S. Kalgutkar et al. · Chemical Research in Toxicology · 2006 · 96 citations

, , +16

Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q‐trap mass spectrometry

Bo Wen, William L. Fitch · Journal of Mass Spectrometry · 2008 · 62 citations

, , +17

Use of a Trapping Agent for Simultaneous Capturing and High-Throughput Screening of Both “Soft” and “Hard” Reactive Metabolites

Zhengyin Yan, Noureddine Maher, Rhoda Torres et al. · Analytical Chemistry · 2007 · 54 citations

, , +17

1–5 of 47

Authors

200

  1. MA
    Moa Andresen Bergström

    University of Gothenburg, Sweden

    2 publications · 57 citations

    2

    h-index

  2. AS
    Amit S. Kalgutkar

    Pfizer (United States), United States

    2 publications · 126 citations

    2

    h-index

  3. ZY
    Zhengyin Yan

    Johnson & Johnson (United States), United States

    2 publications · 181 citations

    2

    h-index

  4. CJ
    Charlotte Jonsson

    University of Gothenburg, Sweden

    1 publications · 33 citations

    1

    h-index

  5. HT
    Hiroyuki Takahashi

    The University of Tokyo, Japan

    1 publications · 40 citations

    1

    h-index

1–5 of 200

Institutions

68

  1. Johnson & Johnson (United States)

    New Brunswick, United States

    3 h-index

    7 publications

    496 citations

  2. AstraZeneca (Sweden)

    Södertälje, Sweden

    3 h-index

    13 publications

    259 citations

  3. Dartmouth College

    Hanover, United States

    2 h-index

    4 publications

    116 citations

  4. Pfizer (United States)

    New York, United States

    2 h-index

    8 publications

    702 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    3 publications

    40 citations

  6. Newcastle University

    Newcastle upon Tyne, United Kingdom

    1 h-index

    1 publications

    10 citations

  7. University of KwaZulu-Natal

    Durban, South Africa

    1 h-index

    7 publications

    70 citations

  8. The Christie Hospital

    Manchester, United Kingdom

    1 h-index

    1 publications

    24 citations

1–8 of 68

Venues

  1. Chemical Research in Toxicology

    6 publications · 381 citations

    6

    h-index

  2. Drug Metabolism and Disposition

    4 publications · 94 citations

    4

    h-index

  3. Journal of Agricultural and Food Chemistry

    3 publications · 91 citations

    3

    h-index

  4. 2

    h-index

  5. Journal of Medicinal Chemistry

    2 publications · 52 citations

    2

    h-index

1–5