Concepedia

Lysosomal Hydrolases

Lysosomal Hydrolases is a class of acid-dependent hydrolytic enzymes localized within lysosomes that catalyze the degradation of macromolecules such as proteins, lipids, nucleic acids, and polysaccharides, distinguished by their optimal activity at acidic pH and their essential role in intracellular digestion and recycling processes.

1.2K

Publications

74.5K

Citations

3.7K

Authors

951

Institutions

Publications per year

2017–2026

64

Variants

Acid HydrolaseAcid HydrolasesLysosomal Hydrolase

Parents

Publications

1.2K

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Ralph A. Nixon, Jerzy Węgiel, Asok Kumar et al. · Journal of Neuropathology & Experimental Neurology · 2005 · 1.6K citations · Full text

, , +14

Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy

Isei Tanida, Naoko Minematsu‐Ikeguchi, Takashi Ueno et al. · Autophagy · 2005 · 1.1K citations

, , +10

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

Alfonso González‐Noriega, Jeffrey H. Grubb, Venugopal D. Talkad et al. · The Journal of Cell Biology · 1980 · 742 citations · Full text

, , +13

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

Jianqiang Fan, Naoki Asano, Yoshiyuki Suzuki · Nature Medicine · 1999 · 613 citations

, , +14

A rapid method for the preparation of microvilli from rabbit kidney

Andrew Booth, A J Kenny · Biochemical Journal · 1974 · 608 citations · Full text

, , +7

1–5 of 1.2K

Authors

3.7K

  1. SK
    Stuart Kornfeld

    Washington University in St. Louis, United States

    30 publications · 2.7K citations

    28

    h-index

  2. AL
    Al L. Tappel

    University of California, Davis, United States

    19 publications · 1K citations

    16

    h-index

  3. GW
    Gerald Weissmann

    New York University, United States

    16 publications · 2.4K citations

    15

    h-index

  4. HK
    Harold Koenig

    Northwestern University, United States

    15 publications · 899 citations

    13

    h-index

  5. WS
    William S. Sly

    Saint Louis University, United States

    12 publications · 2.2K citations

    11

    h-index

1–5 of 3.7K

Institutions

951

  1. Washington University in St. Louis

    St Louis, United States

    29 h-index

    116 publications

    8.5K citations

  2. National Institutes of Health

    Bethesda, United States

    26 h-index

    108 publications

    13.9K citations

  3. New York University

    New York, United States

    22 h-index

    81 publications

    16K citations

  4. University of California San Diego

    San Diego, United States

    18 h-index

    62 publications

    4.3K citations

  5. University of California, Davis

    Davis, United States

    16 h-index

    52 publications

    2.5K citations

  6. Rockefeller University

    New York, United States

    15 h-index

    31 publications

    4.6K citations

  7. Northwestern University

    Evanston, United States

    13 h-index

    39 publications

    3.4K citations

  8. Lund University

    Lund, Sweden

    12 h-index

    29 publications

    804 citations

1–8 of 951

Venues

  1. Journal of Biological Chemistry

    JBC · 80 publications · 7K citations

    50

    h-index

  2. The Journal of Cell Biology

    JCB · 57 publications · 7.3K citations

    41

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 33 publications · 5K citations

    32

    h-index

  4. PubMed

    Repository · 74 publications · 1.9K citations

    25

    h-index

  5. Biochemical Journal

    19 publications · 1.1K citations

    18

    h-index

1–5