William S. Sly

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

Alfonso González‐Noriega, Jeffrey H. Grubb, Venugopal D. Talkad et al. · The Journal of Cell Biology · 1980 · 742 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

Sergey V. Ivanov, Shu‐Yuan Liao, Alla Ivanova et al. · American Journal Of Pathology · 2001 · 683 citations · Full text

Medicine, Molecular Biology, Oncology +14

Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification.

William S. Sly, David Hewett‐Emmett, Michael P. Whyte et al. · Proceedings of the National Academy of Sciences · 1983 · 622 citations · Full text

Life Sciences, Biochemistry, Genetics +17

Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts.

A Kaplan, Daniel T. Achord, William S. Sly · Proceedings of the National Academy of Sciences · 1977 · 576 citations · Full text

Life Sciences, Biochemistry, Cell Biology +11

HFE gene knockout produces mouse model of hereditary hemochromatosis

Xiao Zhou, Shunji Tomatsu, Robert E. Fleming et al. · Proceedings of the National Academy of Sciences · 1998 · 528 citations

Medicine, Genetics, Molecular Genetics +17