Concepedia

Long-range Enhancer Function

Long-Range Enhancer Function is a genomic regulatory mechanism that directs tissue-specific gene expression over large genomic distances through chromatin looping interactions between enhancer elements and target promoters, distinguishing it from proximal regulatory mechanisms by its dependence on three-dimensional chromatin architecture and long-range cis-regulatory communication.

56

Publications

4.9K

Citations

358

Authors

149

Institutions

Publications per year

2017–2026

12

Parents

Publications

56

Scanning Human Gene Deserts for Long-Range Enhancers

Marcelo A. Nóbrega, Ivan Ovcharenko, Veena Afzal et al. · Science · 2003 · 601 citations · Full text

, , +10

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

Gabriela G. Loots, Michaela Kneissel, H. J. Keller et al. · Genome Research · 2005 · 438 citations · Full text

, , +14

<i>HERC2</i> rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the <i>OCA2</i> promoter

Mijke Visser, Manfred Kayser, Robert‐Jan Palstra · Genome Research · 2012 · 286 citations · Full text

, , +17

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expression

Gergana Dobreva, Julia Dambacher, Rudolf Grosschedl · Genes & Development · 2003 · 262 citations · Full text

, , +15

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

Iris A. Mastrangelo, Albert J. Courey, J.S. Wall et al. · Proceedings of the National Academy of Sciences · 1991 · 260 citations

, , +17

1–5 of 56

Authors

358

  1. LA
    Laura A. Lettice

    Institute of Genetics and Cancer, United Kingdom

    4 publications · 380 citations

    4

    h-index

  2. SA
    Stephen A. Liebhaber

    University of Pennsylvania, United States

    4 publications · 233 citations

    4

    h-index

  3. YH
    Yugong Ho

    University of Pennsylvania, United States

    3 publications · 201 citations

    3

    h-index

  4. NE
    Nancy E. Cooke

    University of Pennsylvania, United States

    3 publications · 60 citations

    3

    h-index

  5. PF
    Peggy Farnham

    University of Wisconsin–Madison, United States

    3 publications · 162 citations

    3

    h-index

1–5 of 358

Institutions

149

  1. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    12 publications

    388 citations

  2. National Institutes of Health

    Bethesda, United States

    4 h-index

    9 publications

    782 citations

  3. Inserm

    Paris, France

    3 h-index

    5 publications

    141 citations

  4. Lawrence Berkeley National Laboratory

    Berkeley, United States

    3 h-index

    13 publications

    4.7K citations

  5. Harvard University

    Cambridge, United States

    3 h-index

    10 publications

    1.1K citations

  6. University of Southern California

    Los Angeles, United States

    3 h-index

    14 publications

    722 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    13 publications

    427 citations

  8. University of Edinburgh

    Edinburgh, United Kingdom

    3 h-index

    14 publications

    1.4K citations

1–8 of 149

Venues

  1. Nucleic Acids Research

    7 publications · 370 citations

    7

    h-index

  2. Molecular and Cellular Biology

    MCB · 5 publications · 245 citations

    5

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 559 citations

    4

    h-index

  4. Genome Research

    GR · 4 publications · 998 citations

    4

    h-index

  5. PLoS ONE

    3 publications · 167 citations

    3

    h-index

1–5