Concepedia

Log P Optimization

Log P Optimization is a methodological framework within lipophilicity optimization that specifically focuses on the systematic adjustment of a compound's partition coefficient (log P) to enhance its physicochemical and pharmacokinetic properties while maintaining desired biological activity.

63

Publications

4.8K

Citations

303

Authors

115

Institutions

Publications per year

2017–2026

17

Parents

Publications

63

Rules for optimization of biocatalysis in organic solvents

Colja Laane, Sjef Boeren, Kees Vos et al. · Biotechnology and Bioengineering · 1987 · 1.6K citations · Full text

, , +17

Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally active, nonulcerogenic antiinflammatory agents

Michael D. Mullican, Michael W. Wilson, David T. Conner et al. · Journal of Medicinal Chemistry · 1993 · 372 citations · Full text

, , +13

A graph-based genetic algorithm and generative model/Monte Carlo tree search for the exploration of chemical space

Jan H. Jensen · Chemical Science · 2019 · 355 citations · Full text

, , +16

Antileishmanial Pyrazolopyridine Derivatives:  Synthesis and Structure−Activity Relationship Analysis

Heloisa de Mello, Aurea Echevarrı́a, Alice M. R. Bernardino et al. · Journal of Medicinal Chemistry · 2004 · 182 citations

, , +17

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

Benjamin Jeffries, Zhong Wang, Hannah R. Felstead et al. · Journal of Medicinal Chemistry · 2020 · 154 citations · Full text

, , +17

1–5 of 63

Authors

303

  1. JG
    Jérôme Graton

    Nantes Université, France

    2 publications · 266 citations

    2

    h-index

  2. JY
    Jiaqian Yu

    Samsung (China), China

    2 publications · 58 citations

    2

    h-index

  3. MB
    Mohd Basyaruddin Abdul Rahman

    Universiti Putra Malaysia, Malaysia

    2 publications · 63 citations

    2

    h-index

  4. JS
    James S. Scott

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 266 citations

    2

    h-index

  5. LL
    Larry L. Pearce

    National Cancer Institute, United States

    2 publications · 42 citations

    2

    h-index

1–5 of 303

Institutions

115

  1. CentraleSupélec

    Gif-sur-Yvette, France

    2 h-index

    3 publications

    85 citations

  2. Center for Cancer Research

    Bethesda, United States

    2 h-index

    19 publications

    394 citations

  3. National Cancer Institute

    Bethesda, United States

    2 h-index

    19 publications

    394 citations

  4. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    2 publications

    368 citations

  5. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    2 h-index

    5 publications

    644 citations

  6. Universiti Putra Malaysia

    Seri Kembangan, Malaysia

    2 h-index

    8 publications

    262 citations

  7. University of California, Davis

    Davis, United States

    2 h-index

    10 publications

    730 citations

  8. University of Southampton

    Southampton, United Kingdom

    2 h-index

    9 publications

    1.2K citations

1–8 of 115

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 1K citations

    9

    h-index

  2. Chemical and Pharmaceutical Bulletin

    3 publications · 166 citations

    3

    h-index

  3. Arabian Journal of Chemistry

    2 publications · 53 citations

    2

    h-index

  4. Journal of Pharmaceutical Sciences

    2 publications · 34 citations

    2

    h-index

  5. Journal of Chemical Technology & Biotechnology

    2 publications · 113 citations

    2

    h-index

1–5