Concepedia

Larry L. Pearce

LL

4

Publications

110

Citations

4

H-Index

2001

Active since

Affiliations

National Cancer Institute(Current)

National Institutes of Health

Georgetown University Medical Center

Center for Cancer Research

Georgetown University

Larry L. Pearce is an author at National Cancer Institute specializing in medicinal chemistry, drug discovery, and molecular modeling.

Top concepts

Publications per year

2001–2002

4

Publications

4

New Amide-Bearing Benzolactam-Based Protein Kinase C Modulators Induce Enhanced Secretion of the Amyloid Precursor Protein Metabolite sAPPα

Alan P. Kozikowski, Ireneusz Nowak, Pavel A. Petukhov et al. · Journal of Medicinal Chemistry · 2002 · 46 citations · Full text

An Optimized Protein Kinase C Activating Diacylglycerol Combining High Binding Affinity (<i>K</i><sub>i</sub>) with Reduced Lipophilicity (log P)

Kassoum Nacro, Dina M. Sigano, Shunqi Yan et al. · Journal of Medicinal Chemistry · 2001 · 26 citations · Full text

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Structural Basis of RasGRP Binding to High-Affinity PKC Ligands

Suo-Bao Rong, Istvan Enyedy, Lixin Qiao et al. · Journal of Medicinal Chemistry · 2002 · 22 citations · Full text

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Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between <i>sn-1</i> and <i>sn-2</i> Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

Jeewoo Lee, Kee‐Chung Han, Ji‐Hye Kang et al. · Journal of Medicinal Chemistry · 2001 · 16 citations · Full text

, , +15

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