Concepedia

Light Chain Humanization

Light Chain Humanization is a methodological process in antibody engineering whereby the light chain of a non-human immunoglobulin is modified to increase its sequence and structural homology to human counterparts while preserving antigen-binding specificity and affinity.

7

Publications

473

Citations

43

Authors

13

Institutions

Publications per year

2017–2026

2

Parents

Publications

7

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

Josef Vlasak, Marie Claire Bussat, Shi‐Yi Wang et al. · Analytical Biochemistry · 2009 · 246 citations

, , +13

Characterization of monoclonal antibody size variants containing extra light chains

Connie Lu, Dandan Liu, Hongbin Liu et al. · mAbs · 2013 · 61 citations · Full text

, , +14

A humanized monovalent CD3 antibody which can activate homologous complement

E. G. Routledge, IRENE S. LLOYD, Scott D. Gorman et al. · European Journal of Immunology · 1991 · 52 citations

, , +17

Humanization of rabbit monoclonal antibodies via grafting combined Kabat/IMGT/Paratome complementarity-determining regions: Rationale and examples

Yifan Zhang, Mitchell Ho · mAbs · 2017 · 43 citations · Full text

, , +17

Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.

Itai Benhar, Eduardo A. Padlan, Sung Hee Jung et al. · Proceedings of the National Academy of Sciences · 1994 · 35 citations

, , +17

1–5 of 7

Authors

43

  1. EW
    Elsa Wagner‐Rousset

    Center of Immunology Pierre Fabre, France

    1 publications · 246 citations

    1

    h-index

  2. RI
    Roxana Ionescu

    United States Military Academy, United States

    1 publications · 246 citations

    1

    h-index

  3. HW
    Herman Waldmann

    University of Oxford, United Kingdom

    1 publications · 52 citations

    1

    h-index

  4. YZ
    Yifan Zhang

    Lanzhou University, China

    1 publications · 43 citations

    1

    h-index

  5. CL
    Connie Lu

    University of Washington, United States

    1 publications · 61 citations

    1

    h-index

1–5 of 43

Institutions

13

  1. National Cancer Institute

    Bethesda, United States

    2 h-index

    7 publications

    261 citations

  2. Kaiser Permanente South San Francisco Medical Center

    South San Francisco, United States

    1 h-index

    4 publications

    244 citations

  3. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    5 publications

    260 citations

  4. Genesys (United States)

    Daly City, United States

    1 h-index

    1 publications

    61 citations

  5. Technical University of Munich

    Munich, Germany

    1 h-index

    7 publications

    70 citations

  6. Roche Pharma AG (Germany)

    Grenzach-Wyhlen, Germany

    1 h-index

    2 publications

    52 citations

  7. Roche (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    26 citations

  8. Center of Immunology Pierre Fabre

    Saint-Julien-en-Genevois, France

    1 h-index

    5 publications

    1.2K citations

1–8 of 13

Venues

  1. mAbs

    2 publications · 104 citations

    2

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 1 publications · 10 citations

    1

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 35 citations

    1

    h-index

  4. Frontiers in Molecular Biosciences

    1 publications · 26 citations

    1

    h-index

  5. Analytical Biochemistry

    1 publications · 246 citations

    1

    h-index

1–5