Concepedia

Ligand Binding Engineering

Ligand Binding Engineering is a methodological framework within membrane protein engineering that specifically involves the rational design and optimization of protein-ligand interaction interfaces to achieve enhanced or novel binding specificity, affinity, or functional modulation.

109

Publications

5.8K

Citations

623

Authors

197

Institutions

Publications per year

2017–2026

38

Parents

Publications

109

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Tim Clackson, Yang Wu, Leonard W. Rozamus et al. · Proceedings of the National Academy of Sciences · 1998 · 564 citations

, , +17

Minimizing a binding domain from protein A.

Andrew C. Braisted, James A. Wells · Proceedings of the National Academy of Sciences · 1996 · 306 citations

, , +17

Supramolecular fishing for plasma membrane proteins using an ultrastable synthetic host–guest binding pair

Don‐Wook Lee, Kyeng Min Park, Mainak Banerjee et al. · Nature Chemistry · 2010 · 221 citations

, , +12

Ligand‐Dependent Activity Engineering of Glutathione Peroxidase‐Mimicking MIL‐47(V) Metal–Organic Framework Nanozyme for Therapy

Jiangjiexing Wu, Yijun Yu, Yuan Cheng et al. · Angewandte Chemie International Edition · 2020 · 218 citations

, , +17

Ligand Engineering in Nickel Phthalocyanine to Boost the Electrocatalytic Reduction of CO<sub>2</sub>

Kejun Chen, Maoqi Cao, Yiyang Lin et al. · Advanced Functional Materials · 2021 · 185 citations · Full text

, , +17

1–5 of 109

Authors

623

  1. AS
    Arne Skerra

    Technical University of Munich, Germany

    4 publications · 178 citations

    4

    h-index

  2. CS
    Carsten Schmuck

    University of Duisburg-Essen, Germany

    3 publications · 85 citations

    3

    h-index

  3. HW
    Hui Wei

    Nanjing University, China

    2 publications · 247 citations

    2

    h-index

  4. ML
    Ming Lee Tang

    University of California, Riverside, United States

    2 publications · 61 citations

    2

    h-index

  5. JW
    Junyan Wang

    Chinese Academy of Sciences, China

    2 publications · 89 citations

    2

    h-index

1–5 of 623

Institutions

197

  1. Stanford University

    Stanford, United States

    5 h-index

    16 publications

    694 citations

  2. University of California, Irvine

    Irvine, United States

    4 h-index

    17 publications

    351 citations

  3. Technical University of Munich

    Munich, Germany

    4 h-index

    10 publications

    419 citations

  4. Peking University

    Beijing, China

    3 h-index

    8 publications

    324 citations

  5. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    6 publications

    257 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    10 publications

    532 citations

  7. Irvine University

    Cerritos, United States

    3 h-index

    11 publications

    213 citations

  8. Biotechnology Institute

    Washington D.C., United States

    3 h-index

    3 publications

    181 citations

1–8 of 197

Venues

  1. Angewandte Chemie International Edition

    8 publications · 618 citations

    8

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 373 citations

    7

    h-index

  3. Angewandte Chemie

    5 publications · 86 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 988 citations

    4

    h-index

  5. Bioconjugate Chemistry

    3 publications · 41 citations

    3

    h-index

1–5