Concepedia

Library Size Optimization

Library Size Optimization is a methodological framework in antibody library construction that determines the optimal diversity of a phage or yeast display library to maximize the probability of identifying high-affinity binders while minimizing resource constraints and experimental complexity.

49

Publications

2.3K

Citations

236

Authors

100

Institutions

Publications per year

2017–2026

14

Variants

Library Size Optimisation

Parents

Publications

49

A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions

J. Keith Joung, Elizabeth Ramm, Carl O. Pabo · Proceedings of the National Academy of Sciences · 2000 · 363 citations

, , +14

Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening

Ji-Hu Zhang, Glenn Dawes, Willem P.C. Stemmer · Proceedings of the National Academy of Sciences · 1997 · 274 citations

, , +15

When Second Best Is Good Enough: Another Probabilistic Look at Saturation Mutagenesis

Yuval Nov · Applied and Environmental Microbiology · 2011 · 123 citations · Full text

, , +14

Optimization of an RNA-Seq Differential Gene Expression Analysis Depending on Biological Replicate Number and Library Size

Sophie Lamarre, Pierre Frasse, Mohamed Zouine et al. · Frontiers in Plant Science · 2018 · 114 citations · Full text

, , +14

A DNAzyme with Three Protein‐Like Functional Groups: Enhancing Catalytic Efficiency of M <sup>2+</sup> ‐Independent RNA Cleavage

Marcel Hollenstein, Christopher J. Hipolito, Curtis H. Lam et al. · ChemBioChem · 2009 · 89 citations

, , +15

1–5 of 49

Authors

236

  1. YN
    Yuval Nov

    University of Haifa, Israel

    3 publications · 152 citations

    3

    h-index

  2. SO
    Sijbren Otto

    University of Groningen, Netherlands

    2 publications · 102 citations

    2

    h-index

  3. SM
    Sarah Mayner

    Massachusetts Institute of Technology, United States

    1 publications · 56 citations

    1

    h-index

  4. JX
    Jinbo Xu

    Toyota Technological Institute at Chicago, United States

    1 publications · 17 citations

    1

    h-index

  5. YS
    Yun Shi

    Griffith University, Australia

    1 publications · 30 citations

    1

    h-index

1–5 of 236

Institutions

100

  1. University of Haifa

    Haifa, Israel

    3 h-index

    3 publications

    152 citations

  2. Ghent University

    Ghent, Belgium

    2 h-index

    9 publications

    234 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    5 publications

    448 citations

  4. University of Colorado Boulder

    Boulder, United States

    2 h-index

    9 publications

    300 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    8 publications

    1.4K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    5 publications

    1.2K citations

  7. Universitat de Barcelona

    Barcelona, Spain

    1 h-index

    1 publications

    15 citations

  8. ARUP Institute for Clinical and Experimental Pathology

    Salt Lake City, United States

    1 h-index

    5 publications

    80 citations

1–8 of 100

Venues

  1. Electrophoresis

    2 publications · 43 citations

    2

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 637 citations

    2

    h-index

  3. Frontiers in Plant Science

    2 publications · 128 citations

    2

    h-index

  4. BioTechniques

    2 publications · 33 citations

    2

    h-index

  5. PLoS ONE

    2 publications · 26 citations

    2

    h-index

1–5