Concepedia

Interleukin-18 Processing

Interleukin-18 Processing is a biochemical mechanism within the inflammasome activation pathway that specifically mediates the proteolytic cleavage of inactive pro-Interleukin-18 into its active, secreted cytokine form by caspase-1 or related proteases.

727

Publications

60.7K

Citations

4.7K

Authors

1.2K

Institutions

Publications per year

2017–2026

142

Variants

Il-18 Processing

Parents

Publications

727

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Wanting He, Haoqiang Wan, Lichen Hu et al. · Cell Research · 2015 · 2.5K citations · Full text

, , +16

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Osamu Adachi, Taro Kawai, Kiyoshi Takeda et al. · Immunity · 1998 · 2K citations · Full text

, , +14

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19: anti-inflammatory strategies.

Pio Conti · Journal of Biological Regulators and Homeostatic Agents/Journal of Biological Regulators & Homeostatic Agents · 2020 · 1.3K citations

, , +17

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

Pontus Ørning, Dan Weng, Kristian K. Starheim et al. · Science · 2018 · 1.1K citations · Full text

, , +17

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara Silva Rodrigues, Keyla Santos Guedes de Sá, Adriene Y. Ishimoto et al. · The Journal of Experimental Medicine · 2020 · 855 citations · Full text

, , +16

1–5 of 727

Authors

4.7K

  1. CA
    Charles A. Dinarello

    University of Colorado Denver, United States

    18 publications · 3.7K citations

    16

    h-index

  2. HO
    Haruki Okamura

    Hyogo Medical University, Japan

    16 publications · 1.3K citations

    14

    h-index

  3. MK
    Masashi Kurimoto

    Hayashibara (Japan), Japan

    13 publications · 1.5K citations

    12

    h-index

  4. HT
    Hiroko Tsutsui

    Hyogo Medical University, Japan

    9 publications · 2.9K citations

    9

    h-index

  5. GF
    Giamila Fantuzzi

    University of Illinois Chicago, United States

    9 publications · 2.4K citations

    9

    h-index

1–5 of 4.7K

Institutions

1.2K

  1. Hyogo Medical University

    Nishinomiya, Japan

    21 h-index

    143 publications

    26.4K citations

  2. Hayashibara (Japan)

    Okayama, Japan

    16 h-index

    94 publications

    10K citations

  3. Inserm

    Paris, France

    16 h-index

    76 publications

    6.9K citations

  4. Harvard University

    Cambridge, United States

    15 h-index

    63 publications

    8.3K citations

  5. University of Massachusetts Chan Medical School

    Worcester, United States

    13 h-index

    66 publications

    17.2K citations

  6. The University of Osaka

    Osaka, Japan

    13 h-index

    43 publications

    4.4K citations

  7. National Institutes of Health

    Bethesda, United States

    13 h-index

    48 publications

    2.8K citations

  8. Sookmyung Women's University

    Seoul, South Korea

    12 h-index

    43 publications

    1.5K citations

1–8 of 1.2K

Venues

  1. The Journal of Immunology

    JI · 48 publications · 7.6K citations

    43

    h-index

  2. Cytokine

    32 publications · 1.6K citations

    21

    h-index

  3. PubMed

    Repository · 22 publications · 1.6K citations

    20

    h-index

  4. Journal of Biological Chemistry

    JBC · 16 publications · 1.9K citations

    16

    h-index

  5. European Journal of Immunology

    EJI · 14 publications · 1.1K citations

    14

    h-index

1–5