Concepedia

Interface Mutagenesis

Interface Mutagenesis is a targeted molecular biology technique that introduces specific amino acid substitutions at protein-protein interaction interfaces to systematically probe or modulate the structural and energetic determinants governing quaternary structure assembly.

46

Publications

2.1K

Citations

290

Authors

92

Institutions

Publications per year

2017–2026

8

Parents

Publications

46

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Andrew M. Intlekofer, Alan H. Shih, Bo Wang et al. · Nature · 2018 · 280 citations · Full text

, , +13

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

Hajime Niwa, Caroline A. Ewens, Chun Tsang et al. · Journal of Biological Chemistry · 2012 · 122 citations · Full text

, , +13

Energetic analysis of an antigen/antibody interface: Alanine scanning mutagenesis and double mutant cycles on the hyhel‐10/lysozyme interaction

Jaume Pons, Arvind Rajpal, Jack F. Kirsch · Protein Science · 1999 · 106 citations · Full text

, , +17

Mapping an Interface of SecY (PrlA) and SecE (PrlG) by Using Synthetic Phenotypes and In Vivo Cross-Linking

Chris Harris, Thomas J. Silhavy · Journal of Bacteriology · 1999 · 105 citations · Full text

, , +14

The Structural GDP/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes

Sebastiano Pasqualato, Francesca Senic-Matuglia, Louis Renault et al. · Journal of Biological Chemistry · 2004 · 96 citations · Full text

, , +17

1–5 of 46

Authors

290

  1. BP
    Brendan P. Orner

    Nanyang Technological University, Singapore

    2 publications · 71 citations

    2

    h-index

  2. YZ
    Yu Zhang

    Nanjing Forestry University, China

    2 publications · 71 citations

    2

    h-index

  3. YO
    Yusuke Okada

    Tokyo Institute of Technology, Japan

    1 publications · 26 citations

    1

    h-index

  4. RS
    Reinhard Sterner

    University of Regensburg, Germany

    1 publications · 11 citations

    1

    h-index

  5. FC
    Fernando C. Reinach

    Universidade de São Paulo, Brazil

    1 publications · 51 citations

    1

    h-index

1–5 of 290

Institutions

92

  1. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    11 publications

    660 citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    4 publications

    139 citations

  3. Universidade de São Paulo

    São Paulo, Brazil

    2 h-index

    5 publications

    180 citations

  4. Laboratoire d'Enzymologie et Biochimie Structurales

    Gif-sur-Yvette, France

    2 h-index

    6 publications

    330 citations

  5. Nanyang Technological University

    Singapore, Singapore

    2 h-index

    12 publications

    449 citations

  6. University of Jyväskylä

    Jyväskylä, Finland

    2 h-index

    8 publications

    428 citations

  7. Cornell University

    Ithaca, United States

    2 h-index

    3 publications

    382 citations

  8. Molecular Oncology (United States)

    Gaithersburg, United States

    2 h-index

    6 publications

    800 citations

1–8 of 92

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 413 citations

    8

    h-index

  2. PLoS ONE

    3 publications · 113 citations

    3

    h-index

  3. Journal of Molecular Biology

    JMB · 3 publications · 163 citations

    3

    h-index

  4. Protein Science

    PS · 3 publications · 166 citations

    3

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 3 publications · 75 citations

    3

    h-index

1–5